60 acast.com NPP BrainPod http://www.nature.com/npp/podcast/index.html en American College of Neuropsychopharmacology Springer Nature Neuropsychopharmacology Podcast

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]]> false Marina Ostankovitch info+1b454f3a-002e-540e-82a0-3e5bcb0b5da9@mg-eu.acast.com 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 neuropsychopharmacologypodcast https://rss.acast.com/neuropsychopharmacologypodcast episodic https://assets.pippa.io/shows/61b9f3bd1a8cbe2b563cedcd/1674659784850-2ede8148bf53faf1cecfe09ee0fead3a.jpeg http://www.nature.com/npp/podcast/index.html NPP BrainPod https://feeds.acast.com/public/shows/1b454f3a-002e-540e-82a0-3e5bcb0b5da9 Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles Mon, 23 Feb 2026 21:04:06 GMT 9:44 699cc0c6e58ea9113841a9eb false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/oxytocin-neurons-in-the-anterior-and-posterior-paraventricul 699cc0c6e58ea9113841a9eb 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 oxytocin-neurons-in-the-anterior-and-posterior-paraventricul full Oxytocin has become known for having anti-anxiety and affiliative behavioral effects. That’s why clinicians and researchers are excited about using oxytocin as a potential therapeutic. 


Brian Trainor is a professor at UC Davis, and his lab has been studying this complexity for the past decade. For an animal model, they work with a territorial, aggressive, monogamous rodent species called California mice. If the male is removed and the female is forced to defend their nest, she will experience what’s known as social defeat, and she will exhibit what’s called inhibited affiliative behavior, the type that can be affected by oxytocin — and this effect can be studied in a mouse’s brain.


Read the full study here: https://www.nature.com/articles/s41386-026-02352-y

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]]> Oxytocin has become known for having anti-anxiety and affiliative behavioral effects. That’s why clinicians and researchers are excited about using oxytocin as a potential therapeutic. 


Brian Trainor is a professor at UC Davis, and his lab has been studying this complexity for the past decade. For an animal model, they work with a territorial, aggressive, monogamous rodent species called California mice. If the male is removed and the female is forced to defend their nest, she will experience what’s known as social defeat, and she will exhibit what’s called inhibited affiliative behavior, the type that can be affected by oxytocin — and this effect can be studied in a mouse’s brain.


Read the full study here: https://www.nature.com/articles/s41386-026-02352-y

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]]> The genetics of cannabis lifetime use The genetics of cannabis lifetime use Wed, 07 Jan 2026 20:02:10 GMT 9:53 695ebbc2313b808065d746a3 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/the-genetics-of-cannabis-lifetime-use 695ebbc2313b808065d746a3 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 the-genetics-of-cannabis-lifetime-use full Cannabis, which is increasingly legally available, both for therapeutic and recreational use, is now one of the most commonly used drugs worldwide. Of people who have ever used cannabis, studies vary, but they estimate that about 10-25 percent of people who use cannabis go on to develop cannabis use disorder.


Uri Bright is a postdoctoral associate at the Yale School of Medicine and is one of the authors of a recent study in the journal Neuropsychopharmacology on the genetics of cannabis lifetime use — which is anyone who has ever used cannabis even once. That’s a distinct population from people who have cannabis use disorder, as his colleagues had looked into in the previous study.

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]]> Cannabis, which is increasingly legally available, both for therapeutic and recreational use, is now one of the most commonly used drugs worldwide. Of people who have ever used cannabis, studies vary, but they estimate that about 10-25 percent of people who use cannabis go on to develop cannabis use disorder.


Uri Bright is a postdoctoral associate at the Yale School of Medicine and is one of the authors of a recent study in the journal Neuropsychopharmacology on the genetics of cannabis lifetime use — which is anyone who has ever used cannabis even once. That’s a distinct population from people who have cannabis use disorder, as his colleagues had looked into in the previous study.

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]]> Older and wiser? The neural correlates of worry induction and reappraisal in older adults Older and wiser? The neural correlates of worry induction and reappraisal in older adults Mon, 27 Oct 2025 17:16:14 GMT 9:30 68ffa8de4bfd27f82db16beb false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/older-and-wiser-the-neural-correlates-of-worry-induction-and 68ffa8de4bfd27f82db16beb 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 older-and-wiser-the-neural-correlates-of-worry-induction-and full Worry seems like something most people do from time to time, but for some people, severe worry can become an overwhelming sensation, and for older adults later in life, severe worry has been associated with an increased risk of stroke and coronary heart disease. Carmen Andreescu is a professor of psychiatry and bioengineering at the University of Pittsburgh School of Medicine. She says mild worry is useful evolutionarily, to help us make plans or adapt behavior.


Read the full study here: https://www.nature.com/articles/s41386-025-02193-1

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]]> Worry seems like something most people do from time to time, but for some people, severe worry can become an overwhelming sensation, and for older adults later in life, severe worry has been associated with an increased risk of stroke and coronary heart disease. Carmen Andreescu is a professor of psychiatry and bioengineering at the University of Pittsburgh School of Medicine. She says mild worry is useful evolutionarily, to help us make plans or adapt behavior.


Read the full study here: https://www.nature.com/articles/s41386-025-02193-1

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]]> <![CDATA[Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls]]> Tue, 29 Jul 2025 13:49:01 GMT 8:45 6888d14d7a996a7baaa27b9f false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/grey-matter-morphometry-in-young-adult-e-cigarette-users-tob 6888d14d7a996a7baaa27b9f 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 grey-matter-morphometry-in-young-adult-e-cigarette-users-tob full There’s been a fair amount of animal data suggesting that nicotine can affect the developing brain, but there hadn’t been the equivalent human studies done on people whose brains are still developing. And today there are two predominant forms of nicotine delivery - tobacco cigarettes, and e-cigarettes, or vaping.


Laurie Zawertailo is a senior scientist at the Center for Addiction and Mental Health in Toronto and an associate professor in the department of pharmacology and toxicology at the University of Toronto. Kanwar Boparai recently completed her PhD, working with Dr. Zawertailo, and is now a postdoc. For their new study, they and some colleagues recruited young adults age 18-25, and these people fell into three groups: one that had only smoked cigarettes, one that had only ever vaped, and a third that functioned as a control, that had never used either. They ended up with 26 smokers, 27 vapers, and 25 controls. This is the first human study to separate cigarette smokers and vapers into distinct groups.


Read the full study here: https://www.nature.com/articles/s41386-025-02086-3

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]]> There’s been a fair amount of animal data suggesting that nicotine can affect the developing brain, but there hadn’t been the equivalent human studies done on people whose brains are still developing. And today there are two predominant forms of nicotine delivery - tobacco cigarettes, and e-cigarettes, or vaping.


Laurie Zawertailo is a senior scientist at the Center for Addiction and Mental Health in Toronto and an associate professor in the department of pharmacology and toxicology at the University of Toronto. Kanwar Boparai recently completed her PhD, working with Dr. Zawertailo, and is now a postdoc. For their new study, they and some colleagues recruited young adults age 18-25, and these people fell into three groups: one that had only smoked cigarettes, one that had only ever vaped, and a third that functioned as a control, that had never used either. They ended up with 26 smokers, 27 vapers, and 25 controls. This is the first human study to separate cigarette smokers and vapers into distinct groups.


Read the full study here: https://www.nature.com/articles/s41386-025-02086-3

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]]> Validation of L-type calcium channel blocker amlodipine as a novel ADHD treatment through cross-species analysis, drug-target Mendelian randomization, and clinical evidence from medical records Validation of L-type calcium channel blocker amlodipine as a novel ADHD treatment through cross-species analysis, drug-target Mendelian randomization, and clinical evidence from medical records Wed, 04 Jun 2025 13:58:33 GMT 9:41 68405109c8835d385c206d3a false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/validation-of-l-type-calcium-channel-blocker-amlodipine-as-a 68405109c8835d385c206d3a 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 validation-of-l-type-calcium-channel-blocker-amlodipine-as-a full Attention deficit hyperactivity disorder, or ADHD, is a common condition that, for a lot of people, is difficult to treat. The drugs that exist have a number of adverse side effects, and about 25 percent of patients don’t respond to existing drugs. And so a team of researchers in Iceland, led by Karl Karlsson, professor of biomolecular engineering at Reykjavik University, undertook a number of different steps to narrow in on and then test what the team has determined to be a novel treatment for ADHD, using an existing drug, amlodipine. 


Read the full study here: https://www.nature.com/articles/s41386-025-02062-x

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]]> Attention deficit hyperactivity disorder, or ADHD, is a common condition that, for a lot of people, is difficult to treat. The drugs that exist have a number of adverse side effects, and about 25 percent of patients don’t respond to existing drugs. And so a team of researchers in Iceland, led by Karl Karlsson, professor of biomolecular engineering at Reykjavik University, undertook a number of different steps to narrow in on and then test what the team has determined to be a novel treatment for ADHD, using an existing drug, amlodipine. 


Read the full study here: https://www.nature.com/articles/s41386-025-02062-x

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]]> Rapid and sustained antidepressant effects of vaporized N,N-Dimethyltryptamine: A Phase 2a clinical trial in Treatment-Resistant Depression. Rapid and sustained antidepressant effects of vaporized N,N-Dimethyltryptamine: A Phase 2a clinical trial in Treatment-Resistant Depression. Fri, 18 Apr 2025 18:22:49 GMT 9:52 680298796aefdc1cfc0e8bb4 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/rapid-and-sustained-antidepressant-effects-of-vaporized-nn-d 680298796aefdc1cfc0e8bb4 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 rapid-and-sustained-antidepressant-effects-of-vaporized-nn-d full Draulio Araujo, professor at the Brain Institute in the University of Rio Grande Norte in Natal, Brazil, has been studying ayahuasca for more than 20 years. It’s a psychedelic plant used in rituals in South America that has also been researched for its potential to treat depression. The effects of ayahuasca can last for hours and also lead to side effects including vomiting and diarrhea. The active psychedelic drug in ayahuasca is DMT, and so Dr. Araujo and his colleagues decided to conduct the first test of DMT itself, which is also an endogenous chemical and has been demonstrated to be safe.


Read the full article here: https://www.nature.com/articles/s41386-025-02091-6

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]]> Draulio Araujo, professor at the Brain Institute in the University of Rio Grande Norte in Natal, Brazil, has been studying ayahuasca for more than 20 years. It’s a psychedelic plant used in rituals in South America that has also been researched for its potential to treat depression. The effects of ayahuasca can last for hours and also lead to side effects including vomiting and diarrhea. The active psychedelic drug in ayahuasca is DMT, and so Dr. Araujo and his colleagues decided to conduct the first test of DMT itself, which is also an endogenous chemical and has been demonstrated to be safe.


Read the full article here: https://www.nature.com/articles/s41386-025-02091-6

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]]> Endocannabinoid contributions to the perception of socially relevant, affective touch in humans Endocannabinoid contributions to the perception of socially relevant, affective touch in humans Tue, 04 Mar 2025 15:37:15 GMT 9:13 67c71e2bece4993ac7ce6e1f false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/endocannabinoid-contributions-to-the-perception-of-socially- 67c71e2bece4993ac7ce6e1f 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 endocannabinoid-contributions-to-the-perception-of-socially- full New drugs that target the endocannabinoid system are being proposed for disorders that are usually characterized by the dysregulation of social processing, like social anxiety disorder and autism spectrum disorder. Researchers have been trying to understand the mechanisms for how these drugs work. 


Leah Mayo is assistant professor at the University of Calgary, and she’s one of the authors of a new study in the journal Neuropsychopharmacology in which they examined two aspects of the system. One is the endocannabinoid system itself. And then there’s another aspect of social processing called the C tactile system. 


Read the full study here: Endocannabinoid contributions to the perception of socially relevant, affective touch in humans | Neuropsychopharmacology



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]]> New drugs that target the endocannabinoid system are being proposed for disorders that are usually characterized by the dysregulation of social processing, like social anxiety disorder and autism spectrum disorder. Researchers have been trying to understand the mechanisms for how these drugs work. 


Leah Mayo is assistant professor at the University of Calgary, and she’s one of the authors of a new study in the journal Neuropsychopharmacology in which they examined two aspects of the system. One is the endocannabinoid system itself. And then there’s another aspect of social processing called the C tactile system. 


Read the full study here: Endocannabinoid contributions to the perception of socially relevant, affective touch in humans | Neuropsychopharmacology



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]]> Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats Wed, 15 Jan 2025 00:27:12 GMT 9:46 67852f2278acadca63f3d8fd false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/sex-differences-in-sensitivity-to-dopamine-receptor 67852f2278acadca63f3d8fd 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 sex-differences-in-sensitivity-to-dopamine-receptor full The scientific literature has shown that females demonstrate more aversion to risk-taking than males. Studies have also demonstrated that the basal lateral amygdala, or BLA, is a critical hub for processing risk and reward information. And yet further research has shown that activity in the amygdala differs between males and females, and that the expression of particular dopamine receptors called D2 receptors are greater in females than in males. The authors hypothesized that one mediating mechanism that leads to greater risk aversion in females is differential activity of dopamine in the basal lateral amygdala. 

Caitlin Orsini is an assistant professor in the departments of psychology and neurology at UT Austin. 

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]]> The scientific literature has shown that females demonstrate more aversion to risk-taking than males. Studies have also demonstrated that the basal lateral amygdala, or BLA, is a critical hub for processing risk and reward information. And yet further research has shown that activity in the amygdala differs between males and females, and that the expression of particular dopamine receptors called D2 receptors are greater in females than in males. The authors hypothesized that one mediating mechanism that leads to greater risk aversion in females is differential activity of dopamine in the basal lateral amygdala. 

Caitlin Orsini is an assistant professor in the departments of psychology and neurology at UT Austin. 

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]]> Biomarker development for menstrual Cycle affective change: the need for greater temporal, mechanistic, and phenotypic specificity. Biomarker development for menstrual Cycle affective change: the need for greater temporal, mechanistic, and phenotypic specificity. Mon, 02 Dec 2024 23:05:00 GMT 9:39 674e3cdb603b9bf59a0b6ca2 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/biomarker-development-for-menstrual-cycle-affective-change-t 674e3cdb603b9bf59a0b6ca2 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 biomarker-development-for-menstrual-cycle-affective-change-t full The menstrual cycle is known to affect things like mood and changes in pain. But there can also be symptoms that have a serious impact on a person’s function, ability to work, ability to maintain friendships and romantic relationships. This is a rare condition known as premenstrual dysphoric disorder. But it’s not the only psychiatric condition that can worsen with changes in the menstrual cycle. For instance, nearly 60 percent of menstruating patients with depression can experience cyclical worsening similar to PMDD. Conditions such as these are generally referred to as menstrual cycle affective change. Menstrual cycle affective change is more common in those with chronic psychiatric disorders.

 

The authors are interested in reframing the conversation around menstrual cycle affective change to be something that is a more fundamental process that we can study across disorders, across categories, and identify biomarkers that might help us predict who's going to have those symptoms in more complex ways than we might be able to do with categories. This paper represents how can we take this dimensional way of thinking about menstrual cycle affective change and talk about the specific ways that we can be precise in looking at the time the time characteristics of that, the specific mechanisms, et cetera.

 

Tory Eisenlohr-Moul is an associate professor of psychiatry at the University of Illinois at Chicago in the department of psychiatry, and she’s one of the authors. Jordan Barone is an MD/PhD candidate at the University of Illinois at Chicago, and she’s another author. 

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]]> The menstrual cycle is known to affect things like mood and changes in pain. But there can also be symptoms that have a serious impact on a person’s function, ability to work, ability to maintain friendships and romantic relationships. This is a rare condition known as premenstrual dysphoric disorder. But it’s not the only psychiatric condition that can worsen with changes in the menstrual cycle. For instance, nearly 60 percent of menstruating patients with depression can experience cyclical worsening similar to PMDD. Conditions such as these are generally referred to as menstrual cycle affective change. Menstrual cycle affective change is more common in those with chronic psychiatric disorders.

 

The authors are interested in reframing the conversation around menstrual cycle affective change to be something that is a more fundamental process that we can study across disorders, across categories, and identify biomarkers that might help us predict who's going to have those symptoms in more complex ways than we might be able to do with categories. This paper represents how can we take this dimensional way of thinking about menstrual cycle affective change and talk about the specific ways that we can be precise in looking at the time the time characteristics of that, the specific mechanisms, et cetera.

 

Tory Eisenlohr-Moul is an associate professor of psychiatry at the University of Illinois at Chicago in the department of psychiatry, and she’s one of the authors. Jordan Barone is an MD/PhD candidate at the University of Illinois at Chicago, and she’s another author. 

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]]> Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations Wed, 21 Aug 2024 15:18:42 GMT 9:39 66c60552aba59aa5bb87fc4f false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/genome-wide-association-studies-of-coffee-intake-in-ukus-par 66c60552aba59aa5bb87fc4f 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 genome-wide-association-studies-of-coffee-intake-in-ukus-par full Researchers are interested in understanding the biology of why some people are more likely to overconsume substances. Some substances are difficult to study—people might not admit to illegal substance abuse or to how much alcohol they drink. But Americans are more likely to accurately recall and share how much coffee they drink—which is related to how much caffeine they consume. And so a team of researchers paired up with the company 23 and Me to try to understand genetic differences among a large set of people, to try to tease out any genetic similarities that could be correlated with coffee consumption. Sandra Sanchez-Roige is an associate professor in the department of psychiatry at the University of California San Diego, and she’s one of the study’s authors. Abraham Palmer is a professor and vice chair of basic research in the department of psychiatry at UC San Diego, and he’s another of the study’s authors. 


Read their full study here: https://www.nature.com/articles/s41386-024-01870-x

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]]> Researchers are interested in understanding the biology of why some people are more likely to overconsume substances. Some substances are difficult to study—people might not admit to illegal substance abuse or to how much alcohol they drink. But Americans are more likely to accurately recall and share how much coffee they drink—which is related to how much caffeine they consume. And so a team of researchers paired up with the company 23 and Me to try to understand genetic differences among a large set of people, to try to tease out any genetic similarities that could be correlated with coffee consumption. Sandra Sanchez-Roige is an associate professor in the department of psychiatry at the University of California San Diego, and she’s one of the study’s authors. Abraham Palmer is a professor and vice chair of basic research in the department of psychiatry at UC San Diego, and he’s another of the study’s authors. 


Read their full study here: https://www.nature.com/articles/s41386-024-01870-x

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]]> C-reactive protein moderates associations between racial discrimination and ventromedial prefrontal cortex activation during attention to threat in Black American women C-reactive protein moderates associations between racial discrimination and ventromedial prefrontal cortex activation during attention to threat in Black American women Fri, 21 Jun 2024 14:11:46 GMT 9:56 66758a22d93b3d0012c6f991 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/c-reactive-protein-moderates-associations-between-racial-dis 66758a22d93b3d0012c6f991 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 c-reactive-protein-moderates-associations-between-racial-dis full Scientists have been amassing an increasing amount of evidence about the impact of racial discrimination and racial trauma, including how it can have an impact on brain regions involved with threat vigilance and emotional regulation. At the same time, there’s evidence that increased engagement in those areas has been linked to increased risk of mental health problems like depression, and they also suspect it could be a vulnerability for brain health issues such as dementia and Alzheimer’s disease. 


Negar Fani is an associate professor in the department of psychiatry and behavioral sciences at Emory University School of Medicine, and she worked with Aziz Elbasheir, a PhD candidate at Emory University in the neuroscience program, on the study. They knew that C-reactive proteins, or CRPs, are a marker of immune activation in the blood.


Read their full study here: https://www.nature.com/articles/s41386-023-01737-7

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]]> Scientists have been amassing an increasing amount of evidence about the impact of racial discrimination and racial trauma, including how it can have an impact on brain regions involved with threat vigilance and emotional regulation. At the same time, there’s evidence that increased engagement in those areas has been linked to increased risk of mental health problems like depression, and they also suspect it could be a vulnerability for brain health issues such as dementia and Alzheimer’s disease. 


Negar Fani is an associate professor in the department of psychiatry and behavioral sciences at Emory University School of Medicine, and she worked with Aziz Elbasheir, a PhD candidate at Emory University in the neuroscience program, on the study. They knew that C-reactive proteins, or CRPs, are a marker of immune activation in the blood.


Read their full study here: https://www.nature.com/articles/s41386-023-01737-7

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]]> Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial Mon, 06 May 2024 16:55:36 GMT 9:06 66390b88793d40001322591a false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/ghrelin-decreases-sensitivity-to-negative-feedback-and-incre 66390b88793d40001322591a 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 ghrelin-decreases-sensitivity-to-negative-feedback-and-incre full There’s a hormone called ghrelin that’s secreted in the stomach, and when someone is hungry it contributes to that feeling of hunger and the need to search for food. But neurological studies have suggested that ghrelin might also play a role in compulsivity and impulsivity, and it might be related to substance use disorders.


Rebecca Boeme is an assistant professor at Linkoping University in Sweden. She and her colleagues decided to use human subjects to investigate how ghrelin affects reinforcement learning, basically how ghrelin influences decision making when subjects receive positive and negative feedback —and also how it might actually be affecting the brain. 


Read the full study here: https://www.nature.com/articles/s41386-024-01821-6

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]]> There’s a hormone called ghrelin that’s secreted in the stomach, and when someone is hungry it contributes to that feeling of hunger and the need to search for food. But neurological studies have suggested that ghrelin might also play a role in compulsivity and impulsivity, and it might be related to substance use disorders.


Rebecca Boeme is an assistant professor at Linkoping University in Sweden. She and her colleagues decided to use human subjects to investigate how ghrelin affects reinforcement learning, basically how ghrelin influences decision making when subjects receive positive and negative feedback —and also how it might actually be affecting the brain. 


Read the full study here: https://www.nature.com/articles/s41386-024-01821-6

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]]> Spotlighting SHAPERS: Sex hormones associated with psychological and endocrine roles Spotlighting SHAPERS: Sex hormones associated with psychological and endocrine roles Tue, 05 Mar 2024 14:19:35 GMT 9:08 65e72952ccd9aa0015a57034 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/spotlighting-shapers-ex-hormones-associated-with-psychologic 65e72952ccd9aa0015a57034 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 spotlighting-shapers-ex-hormones-associated-with-psychologic full Dr. Nicole Petersen is an assistant professor in the department of psychiatry and behavioral sciences at UCLA. Her commentary is a new paper in the journal Neuropsychopharmacology, called “Spotlighting SHAPERS: sex hormones associated with psychological and endocrine roles.” Dr. Petersen starts the paper describing an unnamed signaling molecule that can affect the physical structure of the brain and that seems to be related to a wide number of psychological and neurological conditions. Then she reveals that this is estradiol. The point she makes in the paper is that estrogen isn’t the only neuroactive substance that affects the brain in ways that we just don’t understand.


Read the full study here: https://www.nature.com/articles/s41386-024-01819-0

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]]> Dr. Nicole Petersen is an assistant professor in the department of psychiatry and behavioral sciences at UCLA. Her commentary is a new paper in the journal Neuropsychopharmacology, called “Spotlighting SHAPERS: sex hormones associated with psychological and endocrine roles.” Dr. Petersen starts the paper describing an unnamed signaling molecule that can affect the physical structure of the brain and that seems to be related to a wide number of psychological and neurological conditions. Then she reveals that this is estradiol. The point she makes in the paper is that estrogen isn’t the only neuroactive substance that affects the brain in ways that we just don’t understand.


Read the full study here: https://www.nature.com/articles/s41386-024-01819-0

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]]> Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making Thu, 04 Jan 2024 16:42:08 GMT 9:33 6596dfe085908f0016e5e5d3 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/httpswwwnaturecomarticless41386-023-01762-6 6596dfe085908f0016e5e5d3 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 httpswwwnaturecomarticless41386-023-01762-6 full Serotonin is a critical chemical when it comes to a number of psychiatric conditions, such as OCD, where it seems to play a particular role in cognitive flexibility. That is, serotonin levels are related to the fact that someone is perseverating on intrusive thoughts or compulsions and isn’t able to be as flexible as otherwise would be necessary.


Trevor Robbins, professor of cognitive neuroscience at the University of Cambridge, is one of the authors of a recent study titled Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making, and he says such cognitive flexibility also plays a role in depression and schizophrenia.


Read the full study here: https://www.nature.com/articles/s41386-023-01762-6

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]]> Serotonin is a critical chemical when it comes to a number of psychiatric conditions, such as OCD, where it seems to play a particular role in cognitive flexibility. That is, serotonin levels are related to the fact that someone is perseverating on intrusive thoughts or compulsions and isn’t able to be as flexible as otherwise would be necessary.


Trevor Robbins, professor of cognitive neuroscience at the University of Cambridge, is one of the authors of a recent study titled Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making, and he says such cognitive flexibility also plays a role in depression and schizophrenia.


Read the full study here: https://www.nature.com/articles/s41386-023-01762-6

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]]> Integrating public health and translational basic science to address challenges of xylazine adulteration of fentanyl Integrating public health and translational basic science to address challenges of xylazine adulteration of fentanyl Mon, 16 Oct 2023 15:22:16 GMT 9:58 652d5528d40c970012646735 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/integrating-public-health-and-translational-basic-science-to 652d5528d40c970012646735 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 integrating-public-health-and-translational-basic-science-to full The drug naloxone, otherwise known as Narcan, is a critical tool in reversing fentanyl overdoses and reducing mortality. But now fentanyl is appearing on the streets adulterated with a drug called xylazine. 


Justin Strickland, assistant professor at Johns Hopkins University School of Medicine, and Cassandra Gipson-Reichardt, associate professor in the department of pharmacology nutritional sciences at the University of Kentucky, are the coauthors of a new paper in the journal Neuropsychopharmacology about the importance of integrating public health and translational science to address the challenges of xylazine adulteration of fentanyl. 


Read the full study here: https://www.nature.com/articles/s41386-023-01680-7



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]]> The drug naloxone, otherwise known as Narcan, is a critical tool in reversing fentanyl overdoses and reducing mortality. But now fentanyl is appearing on the streets adulterated with a drug called xylazine. 


Justin Strickland, assistant professor at Johns Hopkins University School of Medicine, and Cassandra Gipson-Reichardt, associate professor in the department of pharmacology nutritional sciences at the University of Kentucky, are the coauthors of a new paper in the journal Neuropsychopharmacology about the importance of integrating public health and translational science to address the challenges of xylazine adulteration of fentanyl. 


Read the full study here: https://www.nature.com/articles/s41386-023-01680-7



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]]> The why, when, where, how, and so what of so-called rapidly acting antidepressants The why, when, where, how, and so what of so-called rapidly acting antidepressants Wed, 06 Sep 2023 14:03:54 GMT 8:29 64f886cbb20f810011c58e21 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/the-why-when-where-how-and-so-what-of-so-called-rapidly-acti 64f886cbb20f810011c58e21 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 the-why-when-where-how-and-so-what-of-so-called-rapidly-acti full Sanjay Mathew is a professor and vice chair for research at Baylor College of Medicine and director of the Mood and Anxiety Disorders Program. He’s one of the two authors of a recent review paper in the journal Neuropsychopharmacology, “The why, when, where, how, and so what of so-called rapidly acting antidepressants.”


With his colleague Alan Schatzberg, professor of psychiatry and behavioral sciences and director of the Mood Disorders Center at Stanford University, they explore both the drugs that have been studied as rapidly-acting anti-depressants to date, and they also review the challenges and opportunities in how such research is conducted. They say that a version of ketamine has changed the field.


Read the full study here: https://www.nature.com/articles/s41386-023-01647-8



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]]> Sanjay Mathew is a professor and vice chair for research at Baylor College of Medicine and director of the Mood and Anxiety Disorders Program. He’s one of the two authors of a recent review paper in the journal Neuropsychopharmacology, “The why, when, where, how, and so what of so-called rapidly acting antidepressants.”


With his colleague Alan Schatzberg, professor of psychiatry and behavioral sciences and director of the Mood Disorders Center at Stanford University, they explore both the drugs that have been studied as rapidly-acting anti-depressants to date, and they also review the challenges and opportunities in how such research is conducted. They say that a version of ketamine has changed the field.


Read the full study here: https://www.nature.com/articles/s41386-023-01647-8



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]]> AI-based analysis of social media language predicts addiction treatment dropout at 90 days AI-based analysis of social media language predicts addiction treatment dropout at 90 days Fri, 23 Jun 2023 19:09:49 GMT 9:09 6495edfd66f8a20011923151 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/ai-based-analysis-of-social-media-language-predicts-addictio 6495edfd66f8a20011923151 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 ai-based-analysis-of-social-media-language-predicts-addictio full In-person treatment for substance use disorders is an incredibly important tool, but there’s a high failure rate — more than 50 percent of people who enter drop out within the first month. There hasn’t been a highly accurate method of identifying who might leave and who might succeed, and knowing this could help centers allocate resources to give the right type of assistance to the right people at the right time. One tool available is called the Addiction Severity Index, which is used to help identify the severity of the addiction and thus customize treatment, but it wasn’t developed to gauge whether a patient might drop out entirely. So a team of researchers decided to mine something known as a digital phenotype. 


Dr. Brenda Curtis is a clinical researcher at the National Institute on Drug Abuse Intramural Research Program, and she’s one of the paper’s authors.


Read the full study here: https://www.nature.com/articles/s41386-023-01585-5

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]]> In-person treatment for substance use disorders is an incredibly important tool, but there’s a high failure rate — more than 50 percent of people who enter drop out within the first month. There hasn’t been a highly accurate method of identifying who might leave and who might succeed, and knowing this could help centers allocate resources to give the right type of assistance to the right people at the right time. One tool available is called the Addiction Severity Index, which is used to help identify the severity of the addiction and thus customize treatment, but it wasn’t developed to gauge whether a patient might drop out entirely. So a team of researchers decided to mine something known as a digital phenotype. 


Dr. Brenda Curtis is a clinical researcher at the National Institute on Drug Abuse Intramural Research Program, and she’s one of the paper’s authors.


Read the full study here: https://www.nature.com/articles/s41386-023-01585-5

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]]> Oxytocin effects on amygdala reactivity to angry faces in males and females with ASPD Oxytocin effects on amygdala reactivity to angry faces in males and females with ASPD Fri, 21 Apr 2023 18:46:20 GMT 9:27 6442d9fc8aa57e0011650b0b false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/oxytocin-effects-on-amygdala-reactivity-to-angry-faces-in-ma 6442d9fc8aa57e0011650b0b 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 oxytocin-effects-on-amygdala-reactivity-to-angry-faces-in-ma full Antisocial personality disorder, or ASPD, is a difficult disorder to study. There have been studies on psychopathic individuals, and on youth with psychopathic traits, but most studies on ASPD to date have been on incarcerated adults. A team of researchers at Heidelberg University wanted to study individuals who are not incarcerated and see what these findings could elucidate about the brains, in particular the amygdalas, of individuals with ASPD.


Haang Jeung-Maarse is a medical doctor at Bielfeld University in Germany and is one of the authors of the paper in the journal Neuropsychopharmacology, on the effects of oxytocin on amygdala reactivity to angry faces in males and females with antisocial personality disorder.


Read the full study here: https://www.nature.com/articles/s41386-023-01549-9

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]]> Antisocial personality disorder, or ASPD, is a difficult disorder to study. There have been studies on psychopathic individuals, and on youth with psychopathic traits, but most studies on ASPD to date have been on incarcerated adults. A team of researchers at Heidelberg University wanted to study individuals who are not incarcerated and see what these findings could elucidate about the brains, in particular the amygdalas, of individuals with ASPD.


Haang Jeung-Maarse is a medical doctor at Bielfeld University in Germany and is one of the authors of the paper in the journal Neuropsychopharmacology, on the effects of oxytocin on amygdala reactivity to angry faces in males and females with antisocial personality disorder.


Read the full study here: https://www.nature.com/articles/s41386-023-01549-9

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]]> To dismantle structural racism in science, scientists need to learn how it works To dismantle structural racism in science, scientists need to learn how it works Wed, 22 Feb 2023 15:24:21 GMT 9:54 63f633a5aa5a9a0011ab1356 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/to-dismantle-structural-racism-in-science-scientists-need-to 63f633a5aa5a9a0011ab1356 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 to-dismantle-structural-racism-in-science-scientists-need-to full It’s clear there are diversity issues in science, both in terms of who does or doesn’t receive research grants, as well as who is or isn’t represented at the highest levels of scientific research. When Caleb Weinreb and Daphne Sun began their PhD program at Harvard University Medical School in systems biology, they took this on as an issue. They learned from others in their department, and they eventually created a course on the topic for incoming first year PhD students.

 

As they worked on improving their course over the years, they saw that in science there was a focus on narrowing racial gaps by correcting for implicit bias. For example, there had been a well-known study in which resumes with stereotypically African-American names weren’t considered as seriously as those with stereotypically white names. But the two PhD students realized that efforts to overcome such implicit bias weren’t moving the needle. They recently published a perspective paper in the journal Neuropsychopharmacology called “To dismantle structural racism in science, scientists need to learn how it works.” Caleb Weinreb is now a post-doc in the neuroscience department at Harvard Medical School.


Read the full paper here: https://www.nature.com/articles/s41386-023-01534-2

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]]> It’s clear there are diversity issues in science, both in terms of who does or doesn’t receive research grants, as well as who is or isn’t represented at the highest levels of scientific research. When Caleb Weinreb and Daphne Sun began their PhD program at Harvard University Medical School in systems biology, they took this on as an issue. They learned from others in their department, and they eventually created a course on the topic for incoming first year PhD students.

 

As they worked on improving their course over the years, they saw that in science there was a focus on narrowing racial gaps by correcting for implicit bias. For example, there had been a well-known study in which resumes with stereotypically African-American names weren’t considered as seriously as those with stereotypically white names. But the two PhD students realized that efforts to overcome such implicit bias weren’t moving the needle. They recently published a perspective paper in the journal Neuropsychopharmacology called “To dismantle structural racism in science, scientists need to learn how it works.” Caleb Weinreb is now a post-doc in the neuroscience department at Harvard Medical School.


Read the full paper here: https://www.nature.com/articles/s41386-023-01534-2

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]]> Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity Thu, 22 Dec 2022 18:37:29 GMT 9:59 63a4a3e92a786e00109bff4b false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/low-doses-of-lysergic-acid-diethylamide-lsd-increase-reward- 63a4a3e92a786e00109bff4b 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 low-doses-of-lysergic-acid-diethylamide-lsd-increase-reward- full Psychedelic drugs have received attention recently for their potential use as treatments for psychiatric disorders. Single, high doses of LSD have shown promise for treating depressive disorders. But there’s another way in which people have been using LSD, and it’s what’s known as micro-dosing, taking LSD at below noticeable levels, where it doesn’t seem to have a psychedelic impact—but users say it does in fact have an impact on their overall sense of well-being.


This is just what Harriet de Wit, University of Chicago professor in the department of psychiatry and behavioral neuroscience, wanted to study. Dr. de Wit partnered with James Glazer, a postdoc in psychiatry at Northwestern University.


Read their full study here: Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity | Neuropsychopharmacology (nature.com)

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]]> Psychedelic drugs have received attention recently for their potential use as treatments for psychiatric disorders. Single, high doses of LSD have shown promise for treating depressive disorders. But there’s another way in which people have been using LSD, and it’s what’s known as micro-dosing, taking LSD at below noticeable levels, where it doesn’t seem to have a psychedelic impact—but users say it does in fact have an impact on their overall sense of well-being.


This is just what Harriet de Wit, University of Chicago professor in the department of psychiatry and behavioral neuroscience, wanted to study. Dr. de Wit partnered with James Glazer, a postdoc in psychiatry at Northwestern University.


Read their full study here: Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity | Neuropsychopharmacology (nature.com)

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]]> Sex-dependent risk factors for PTSD: a prospective structural MRI study Sex-dependent risk factors for PTSD: a prospective structural MRI study Tue, 01 Nov 2022 14:09:50 GMT 9:29 636128ae0759420012e3cbe6 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/sex-dependent-risk-factors-for-ptsd-a-prospective-structural 636128ae0759420012e3cbe6 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 sex-dependent-risk-factors-for-ptsd-a-prospective-structural full After a traumatic event, women are more likely to be diagnosed with post-traumatic stress disorder, or PTSD. Research has been conducted on what might be causing this higher rate of diagnoses; for instance, perhaps women had more cumulative trauma in their lives than the men in question. But scientists say that even taking prior childhood trauma into account, women are still diagnosed at a higher rate than men. 


Alyssa Roeckner is a neuroscience PhD candidate at Emory University, she’s in the lab of Dr. Jennifer Stevens, assistant professor in the department of Psychiatry and Behavioral Sciences at Emory University. They are two of the authors of a recent study in NPP titled “Sex-dependent risk factors for PTSD: a prospective structural MRI study.”


Read the full study here: Sex-dependent risk factors for PTSD: a prospective structural MRI study | Neuropsychopharmacology (nature.com)

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]]> After a traumatic event, women are more likely to be diagnosed with post-traumatic stress disorder, or PTSD. Research has been conducted on what might be causing this higher rate of diagnoses; for instance, perhaps women had more cumulative trauma in their lives than the men in question. But scientists say that even taking prior childhood trauma into account, women are still diagnosed at a higher rate than men. 


Alyssa Roeckner is a neuroscience PhD candidate at Emory University, she’s in the lab of Dr. Jennifer Stevens, assistant professor in the department of Psychiatry and Behavioral Sciences at Emory University. They are two of the authors of a recent study in NPP titled “Sex-dependent risk factors for PTSD: a prospective structural MRI study.”


Read the full study here: Sex-dependent risk factors for PTSD: a prospective structural MRI study | Neuropsychopharmacology (nature.com)

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]]> Sex differences in appetitive and reactive aggression Sex differences in appetitive and reactive aggression Tue, 06 Sep 2022 18:10:54 GMT 9:47 63178d2eaba23d001218bb8d false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/sex-differences-in-appetitive-and-reactive-aggression 63178d2eaba23d001218bb8d 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 sex-differences-in-appetitive-and-reactive-aggression full Maladaptive aggression, while not a diagnosable neuropsychiatric disorder on its own, often presents as an important comorbid condition with other neuropsychiatric disorders. But while both men and women can and do display aggression, there’s been a bias to thinking of aggression, in both its adaptive and maladaptive forms, as a male behavior. 


Sam Golden is an assistant professor at the University of Washington in the department of biological structure and also has an appointment in the Center for Excellence in the Neurobiology of Addiction, Pain, and Emotion. He’s one of the authors of a recent study on aggression in the journal Neuropsychopharmacology. 


Read the full study here: Sex differences in appetitive and reactive aggression | Neuropsychopharmacology (nature.com)

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]]> Maladaptive aggression, while not a diagnosable neuropsychiatric disorder on its own, often presents as an important comorbid condition with other neuropsychiatric disorders. But while both men and women can and do display aggression, there’s been a bias to thinking of aggression, in both its adaptive and maladaptive forms, as a male behavior. 


Sam Golden is an assistant professor at the University of Washington in the department of biological structure and also has an appointment in the Center for Excellence in the Neurobiology of Addiction, Pain, and Emotion. He’s one of the authors of a recent study on aggression in the journal Neuropsychopharmacology. 


Read the full study here: Sex differences in appetitive and reactive aggression | Neuropsychopharmacology (nature.com)

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]]> What’s wrong with my experiment?: The impact of hidden variables on neuropsychopharmacology research What’s wrong with my experiment?: The impact of hidden variables on neuropsychopharmacology research Thu, 16 Jun 2022 17:39:55 GMT 9:34 62ab6aeb444baf0013779c94 false https://www.nature.com/articles/s41386-022-01309-1 62ab6aeb444baf0013779c94 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 whats-wrong-with-my-experiment-the-impact-of-hidden-variable full Sometimes, when researchers are conducting an experiment, the results are confusing. Maybe the control group of animals doesn’t behave the way a control should in theory be behaving. Maybe a researcher repeats a study and sees results that are unusually different from the first time around. The answers to these issues might lie in something called ‘hidden variables,’ according to a new study titled, “What’s wrong with my research? The impact of hidden variables on neuropsychopharmacology research.”

 

Brian Trainor is a professor of psychology at the University of California Davis, and he’s one of three authors of the study. His co-authors are Amanda Kentner, professor at the Massachusetts College of Pharmacy and Health Sciences, and Hannah Butler-Struben, a graduate student in the animal behavior group at UC Davis. They say that many of the articles in the review are from journals about animal behavior that wouldn’t typically come across the desk of those working in the field of neuroscience.


Read the full article here: What’s wrong with my experiment?: The impact of hidden variables on neuropsychopharmacology research


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]]> Sometimes, when researchers are conducting an experiment, the results are confusing. Maybe the control group of animals doesn’t behave the way a control should in theory be behaving. Maybe a researcher repeats a study and sees results that are unusually different from the first time around. The answers to these issues might lie in something called ‘hidden variables,’ according to a new study titled, “What’s wrong with my research? The impact of hidden variables on neuropsychopharmacology research.”

 

Brian Trainor is a professor of psychology at the University of California Davis, and he’s one of three authors of the study. His co-authors are Amanda Kentner, professor at the Massachusetts College of Pharmacy and Health Sciences, and Hannah Butler-Struben, a graduate student in the animal behavior group at UC Davis. They say that many of the articles in the review are from journals about animal behavior that wouldn’t typically come across the desk of those working in the field of neuroscience.


Read the full article here: What’s wrong with my experiment?: The impact of hidden variables on neuropsychopharmacology research


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]]> A scientific approach to navigating the academic job market A scientific approach to navigating the academic job market Mon, 09 May 2022 18:34:27 GMT 7:04 62795eb3fcc96b001542d755 false https://www.nature.com/articles/s41386-021-01225-w 62795eb3fcc96b001542d755 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 a-scientific-approach-to-navigating-the-academic-job-market full Kirstie Cummings and Sofia Beas are both new assistant professors in the department of neurobiology at the University of Alabama, Birmingham. When they met, they discussed the job application process, their support network, and their own personal processes, and they decided to write an article that could serve as a resource for candidates from different backgrounds, many of whom might not have the same resources that Dr. Cummings and Dr. Beas did. The result was their paper, “A Scientific Approach to Navigating the Academic Job Market,” published in the journal Neuropsychopharmacology.


Read the full article here: A scientific approach to navigating the academic job market | Neuropsychopharmacology (nature.com)

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]]> Kirstie Cummings and Sofia Beas are both new assistant professors in the department of neurobiology at the University of Alabama, Birmingham. When they met, they discussed the job application process, their support network, and their own personal processes, and they decided to write an article that could serve as a resource for candidates from different backgrounds, many of whom might not have the same resources that Dr. Cummings and Dr. Beas did. The result was their paper, “A Scientific Approach to Navigating the Academic Job Market,” published in the journal Neuropsychopharmacology.


Read the full article here: A scientific approach to navigating the academic job market | Neuropsychopharmacology (nature.com)

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]]> Identification of THC impairment using functional brain imaging Identification of THC impairment using functional brain imaging Wed, 23 Feb 2022 17:27:57 GMT 9:17 62166e9dcdf63200131cfb7c false https://www.nature.com/npp/podcast 62166e9dcdf63200131cfb7c 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 identification-of-thc-impairment-using-functional-brain-imag full Driving while under the influence of THC, known as drugged driving, is becoming more of an issue as more states legalize cannabis for both medical and recreational use around the country. THC is known to impair cognitive and psychomotor performance and thus impair driving. Jodi Gilman is a neuroscientist and an associate professor of psychiatry at Mass General Hospital and Harvard Medical School, and she’s one of the authors of a new study in the journal Neuropsychopharmacology. She says that impairment and exposure are easier to correlate with alcohol. But tolerance to THC is so vastly different among different people, and the amounts that people use whether for pain or to get high are also so vastly different, that people can have detectible amounts of THC in their system, but it does not necessarily correlate with whether or not that person is too impaired to drive. Listen in to hear what she and her team did to try to detect brain impairment under the influence of THC.


Read the full article here: https://www.nature.com/articles/s41386-021-01259-0

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]]> Driving while under the influence of THC, known as drugged driving, is becoming more of an issue as more states legalize cannabis for both medical and recreational use around the country. THC is known to impair cognitive and psychomotor performance and thus impair driving. Jodi Gilman is a neuroscientist and an associate professor of psychiatry at Mass General Hospital and Harvard Medical School, and she’s one of the authors of a new study in the journal Neuropsychopharmacology. She says that impairment and exposure are easier to correlate with alcohol. But tolerance to THC is so vastly different among different people, and the amounts that people use whether for pain or to get high are also so vastly different, that people can have detectible amounts of THC in their system, but it does not necessarily correlate with whether or not that person is too impaired to drive. Listen in to hear what she and her team did to try to detect brain impairment under the influence of THC.


Read the full article here: https://www.nature.com/articles/s41386-021-01259-0

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]]> Evolution of prefrontal cortex Evolution of prefrontal cortex Mon, 31 Jan 2022 15:42:33 GMT 9:22 61f803696bb2bb0014767c02 false https://shows.acast.com/neuropsychopharmacologypodcast/episodes/evolution-of-prefrontal-cortex 61f803696bb2bb0014767c02 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 evolution-of-prefrontal-cortex full Neuropsychopharmacology called “Evolution of prefrontal cortex.”  Listen in!

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]]> Neuropsychopharmacology called “Evolution of prefrontal cortex.”  Listen in!

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]]> Astrocyte-neuron signaling in the mesolimbic dopamine system: the hidden stars of dopamine signaling Astrocyte-neuron signaling in the mesolimbic dopamine system: the hidden stars of dopamine signaling Mon, 01 Nov 2021 19:03:00 GMT 9:43 2dad42c7-5be5-48d9-b575-25a870d9da5b false https://play.acast.com/s/neuropsychopharmacologypodcast/astrocyte-neuronsignalinginthemesolimbicdopaminesystem-thehiddenstarsofdopaminesignaling 2dad42c7-5be5-48d9-b575-25a870d9da5b 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 astrocyte-neuronsignalinginthemesolimbicdopaminesystem-thehiddenstarsofdopaminesignaling Star-shaped cells called astrocytes are the most abundant cells to be found in the human brain. In the past, they’d been thought to play a supporting role to neurons, such as providing metabolic support, but recently they’re also emerging as stars of i... full

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]]>

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]]> Neurobiology of loneliness: a systematic review Neurobiology of loneliness: a systematic review Mon, 13 Sep 2021 19:11:12 GMT 8:11 87e3c26b-1b6b-4843-a32f-336e33dd15d4 false https://play.acast.com/s/neuropsychopharmacologypodcast/neurobiologyofloneliness-asystematicreview 87e3c26b-1b6b-4843-a32f-336e33dd15d4 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 neurobiologyofloneliness-asystematicreview Loneliness is a subjective experience, but neuroscientists define it as a distress that arrives from a discrepancy between perceived and desired social relationships. There may be an evolutionary benefit to the feeling of loneliness; we’re a social spe... full Loneliness is a subjective experience, but neuroscientists define it as a distress that arrives from a discrepancy between perceived and desired social relationships. There may be an evolutionary benefit to the feeling of loneliness; we’re a social species, and feeling lonely might have sent us to seek out other humans, which has been very important for survival. Moreover, if gone unaddressed and isolation worsens, health effects of loneliness have been shown to double mortality rates. It's linked to cardiovascular disease, metabolic disease, cognitive decline, higher rates of dementia, and poor mental health outcomes (i.e. depression and anxiety).


With loneliness implicated in so many cognitive impacts, Dr. Lee and her colleagues wanted to understand what is known to date about the impact of loneliness on the brain. They conducted a systematic review of the published research that examines loneliness and resulting neurobiological assessments, such as imaging studies, EEG studies, and pathological studies. Listen in and read to learn more!

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]]> Loneliness is a subjective experience, but neuroscientists define it as a distress that arrives from a discrepancy between perceived and desired social relationships. There may be an evolutionary benefit to the feeling of loneliness; we’re a social species, and feeling lonely might have sent us to seek out other humans, which has been very important for survival. Moreover, if gone unaddressed and isolation worsens, health effects of loneliness have been shown to double mortality rates. It's linked to cardiovascular disease, metabolic disease, cognitive decline, higher rates of dementia, and poor mental health outcomes (i.e. depression and anxiety).


With loneliness implicated in so many cognitive impacts, Dr. Lee and her colleagues wanted to understand what is known to date about the impact of loneliness on the brain. They conducted a systematic review of the published research that examines loneliness and resulting neurobiological assessments, such as imaging studies, EEG studies, and pathological studies. Listen in and read to learn more!

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]]> Medial orbitofrontal cortex dopamine D1/D2 receptors differentially modulate distinct forms of probabilistic decision-making Medial orbitofrontal cortex dopamine D1/D2 receptors differentially modulate distinct forms of probabilistic decision-making Tue, 20 Jul 2021 15:06:05 GMT 8:58 5248b0fe-f590-4437-a585-3ebe66bf57c6 false https://play.acast.com/s/neuropsychopharmacologypodcast/medialorbitofrontalcortexdopamined1-d2receptorsdifferentiallymodulatedistinctformsofprobabilisticdecision-making 5248b0fe-f590-4437-a585-3ebe66bf57c6 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 medialorbitofrontalcortexdopamined1-d2receptorsdifferentiallymodulatedistinctformsofprobabilisticdecision-making It’s known that dopamine transmission in the brain, particularly in the frontal lobes, can affect decision-making and can regulate choices when it comes to actions and rewards. But the effect of dopamine transition in the medial orbital frontal cortex ... full

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]]> Addiction as a brain disease revised: why it still matters, and the need for consilience Addiction as a brain disease revised: why it still matters, and the need for consilience Fri, 21 May 2021 04:00:00 GMT 9:54 880dfd6b-044a-4608-9477-2ba97d983448 false https://play.acast.com/s/neuropsychopharmacologypodcast/addictionasabraindiseaserevised-whyitstillmatters-andtheneedforconsilience 880dfd6b-044a-4608-9477-2ba97d983448 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 addictionasabraindiseaserevised-whyitstillmatters-andtheneedforconsilience Nearly 25 years ago, a paper was published about addiction that transformed the field. The director of the US National Institute on Drug Abuse at the time called addiction a “brain disease,” and he wrote a paper articulating this position and the agend... full

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]]> Big data in psychiatry: multiomics, neuroimaging, computational modeling, and digital phenotyping Big data in psychiatry: multiomics, neuroimaging, computational modeling, and digital phenotyping Fri, 19 Mar 2021 04:00:00 GMT 9:51 3831eac9-4fe6-4b67-9167-2129099bb83c false https://play.acast.com/s/neuropsychopharmacologypodcast/bigdatainpsychiatry-multiomics-neuroimaging-computationalmodeling-anddigitalphenotyping 3831eac9-4fe6-4b67-9167-2129099bb83c 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 bigdatainpsychiatry-multiomics-neuroimaging-computationalmodeling-anddigitalphenotyping The world of medicine has been changing rapidly due to the increasing use of ‘big data.’ And there’s been a major revolution in this approach in neuroscience and psychiatry as well: computing power, sample sizes, neuroimaging technologies, digital appr... full Neuropsychopharmacology recently published a Reviews issue on the topic of Big Data. Kerry Ressler, chief scientific officer at McLean hospital and professor of psychiatry at Harvard medical school, is one of the editors.

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]]> Neuropsychopharmacology recently published a Reviews issue on the topic of Big Data. Kerry Ressler, chief scientific officer at McLean hospital and professor of psychiatry at Harvard medical school, is one of the editors.

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]]> Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects Tue, 19 Jan 2021 19:20:56 GMT 9:44 1ae96b21-a327-4e5f-9373-a2954cfd2c2c false https://play.acast.com/s/neuropsychopharmacologypodcast/acutedose-dependenteffectsoflysergicaciddiethylamideinadouble-blindplacebo-controlledstudyinhealthysubjects 1ae96b21-a327-4e5f-9373-a2954cfd2c2c 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 acutedose-dependenteffectsoflysergicaciddiethylamideinadouble-blindplacebo-controlledstudyinhealthysubjects Interest is growing in the use of the psychedelic drug LSD for psychiatric research and even potentially for treatment. But placebo-controlled studies conducted to date have used just one dose of the drug—none have investigated the impacts of a variety... full

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]]> Big behavior: challenges and opportunities in a new era of deep behavior profiling Big behavior: challenges and opportunities in a new era of deep behavior profiling Wed, 04 Nov 2020 05:00:00 GMT 9:31 7636df7f-6c8d-49ec-ab8c-911ac571e659 false https://play.acast.com/s/neuropsychopharmacologypodcast/bigbehavior-challengesandopportunitiesinaneweraofdeepbehaviorprofiling 7636df7f-6c8d-49ec-ab8c-911ac571e659 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 bigbehavior-challengesandopportunitiesinaneweraofdeepbehaviorprofiling Scientists who study neuropsychiatric conditions and treatments often use rodent models to do so. From depression to anxiety to memory impairment and impulsivity, there are certain rodent behaviors that are used to represent these types of conditions i... full Neuropsychopharmacology, along with a review of the field. 

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]]> Neuropsychopharmacology, along with a review of the field. 

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]]> Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders Wed, 23 Sep 2020 04:00:00 GMT 9:49 1306cb79-f2ac-47e2-a216-52dd170788e6 false https://play.acast.com/s/neuropsychopharmacologypodcast/leveraginglargegenomicdatasetstoilluminatethepathobiologyofautismspectrumdisorders 1306cb79-f2ac-47e2-a216-52dd170788e6 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 leveraginglargegenomicdatasetstoilluminatethepathobiologyofautismspectrumdisorders The application of the study of genetics and the use of big data to identify patterns of inheritance as well as de novo mutations has had a dramatic impact on the field of Autism Spectrum Disorder research, and it offers pathways to a greater understan... full Neuropsychopharmacology, called “Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders.” Have a listen to learn more!

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]]> Neuropsychopharmacology, called “Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders.” Have a listen to learn more!

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]]> Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain Fri, 10 Jul 2020 14:15:40 GMT 9:28 2bb2fe09-2517-4bc1-95ab-82ae080b199f false https://play.acast.com/s/neuropsychopharmacologypodcast/pubertaladversityalterschromatindynamicsandstresscircuitryinthepregnantbrain 2bb2fe09-2517-4bc1-95ab-82ae080b199f 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 pubertaladversityalterschromatindynamicsandstresscircuitryinthepregnantbrain It’s understood in epidemiological research that women who experience trauma during puberty are at significantly higher risk for affective disorders such as depression and anxiety when they become pregnant. And so Tracy Bale, a professor in the departm... full Neuropsychopharmacology, she and her colleagues set out to study just what was happening to make the mouse brain so vulnerable to stress and trauma during puberty, and how this was activated during the hormonal onslaught of pregnancy.

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]]> Neuropsychopharmacology, she and her colleagues set out to study just what was happening to make the mouse brain so vulnerable to stress and trauma during puberty, and how this was activated during the hormonal onslaught of pregnancy.

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]]> Social networking and mental health: looking beyond frequency of use and towards mechanisms of action Social networking and mental health: looking beyond frequency of use and towards mechanisms of action Fri, 15 May 2020 04:00:00 GMT 9:32 02f9f9e9-192a-4848-9309-7970b5d01b0b false https://play.acast.com/s/neuropsychopharmacologypodcast/socialnetworkingandmentalhealth-lookingbeyondfrequencyofuseandtowardsmechanismsofaction 02f9f9e9-192a-4848-9309-7970b5d01b0b 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 socialnetworkingandmentalhealth-lookingbeyondfrequencyofuseandtowardsmechanismsofaction Over the past decades, there’s clearly been a dramatic increase in the amount of time people spend online using social networking sites. For instance, Facebook and Instagram have literally billions of users. At the same time, there’s been a rise in men... full

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]]> Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects Fri, 06 Mar 2020 21:47:35 GMT 9:07 ccf20439-bc26-4bf2-8f0a-9717f653029b false https://play.acast.com/s/neuropsychopharmacologypodcast/distinctacuteeffectsoflsd-mdma-andd-amphetamineinhealthysubjects ccf20439-bc26-4bf2-8f0a-9717f653029b 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 distinctacuteeffectsoflsd-mdma-andd-amphetamineinhealthysubjects A number of drugs that are used recreationally are now being studied for their use in psychopharmacology. But while the ways in which these drugs are similar or different has been described anecdotally by recreational users, they haven’t been studied i... full Neuropsychopharmacology, in which 28 healthy subjects, men and women, take doses of LSD, MDMA, amphetamines, and a placebo over four different sessions. Dr. Liechti says this blinding is important; in other studies, participants either have taken a drug or a placebo and can tell when they’re taking the drug. But in this case they don’t know which drug they’re taking, which allows the effects of the drugs to be compared against each other. Take a listen to find out more!

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]]> Neuropsychopharmacology, in which 28 healthy subjects, men and women, take doses of LSD, MDMA, amphetamines, and a placebo over four different sessions. Dr. Liechti says this blinding is important; in other studies, participants either have taken a drug or a placebo and can tell when they’re taking the drug. But in this case they don’t know which drug they’re taking, which allows the effects of the drugs to be compared against each other. Take a listen to find out more!

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]]> Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma Fri, 17 Jan 2020 15:25:51 GMT 9:18 8886961d-de1c-4fe7-909f-7395bdf64e09 false https://play.acast.com/s/neuropsychopharmacologypodcast/chronicopioidpretreatmentpotentiatesthesensitizationoffearlearningbytrauma 8886961d-de1c-4fe7-909f-7395bdf64e09 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 chronicopioidpretreatmentpotentiatesthesensitizationoffearlearningbytrauma It’s known that there’s a relationship between post-traumatic stress disorder, or PTSD, and a higher rate of opioid abuse. What isn’t understood, though, is what that relationship is. Does PTSD cause people to turn to opioids in particular among all th... full It’s known that there’s a relationship between post-traumatic stress disorder, or PTSD, and a higher rate of opioid abuse. What isn’t understood, though, is what that relationship is. Does PTSD cause people to turn to opioids in particular among all the potential drugs of abuse, or is there something about opioid use that makes users particularly sensitive to trauma?


This is just what Michael Fanselow, professor in the psychology and psychiatry departments at UCLA, and his colleagues investigated for a recent study in the journal Neuropsychopharmacology.

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]]> It’s known that there’s a relationship between post-traumatic stress disorder, or PTSD, and a higher rate of opioid abuse. What isn’t understood, though, is what that relationship is. Does PTSD cause people to turn to opioids in particular among all the potential drugs of abuse, or is there something about opioid use that makes users particularly sensitive to trauma?


This is just what Michael Fanselow, professor in the psychology and psychiatry departments at UCLA, and his colleagues investigated for a recent study in the journal Neuropsychopharmacology.

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]]> Effects of MDMA on attention to positive social cues and pleasantness of affective touch. Effects of MDMA on attention to positive social cues and pleasantness of affective touch. Thu, 19 Sep 2019 14:47:36 GMT 9:34 ABD59A5B-86F2-479D-BA1A-B8454E4D4F0F false https://play.acast.com/s/neuropsychopharmacologypodcast/effectsofmdmaonattentiontopositivesocialcuesandpleasantnessofaffectivetouch- c4ae3fcc-e5fc-49f4-8cd1-6f77d13cc464 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 effectsofmdmaonattentiontopositivesocialcuesandpleasantnessofaffectivetouch- Effects of MDMA on attention to positive social cues and pleasantness of affective touch. full

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]]> Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial. Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial. Tue, 16 Jul 2019 14:47:36 GMT 9:34 GGD59A5B-86F2-479D-BA1A-B8454E4D4F0F false https://play.acast.com/s/neuropsychopharmacologypodcast/superolateralmedialforebrainbundledeepbrainstimulationinmajordepression-agatewaytrial- ea444dab-ac0a-4285-be8d-a630df999c0a 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 superolateralmedialforebrainbundledeepbrainstimulationinmajordepression-agatewaytrial- Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial. full

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]]> Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement Fri, 17 May 2019 14:47:36 GMT 9:34 FFD59A5B-86F2-479D-BA1A-B8454E4D4F0F false https://play.acast.com/s/neuropsychopharmacologypodcast/cuesplayacriticalroleinestrouscycle-dependentenhancementofcocainereinforcement 9703c19b-147f-463d-a451-263b7309e02d 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 cuesplayacriticalroleinestrouscycle-dependentenhancementofcocainereinforcement Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement full

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]]> Food Addiction: A Valid Concept? Food Addiction: A Valid Concept? Fri, 08 Mar 2019 14:47:36 GMT 9:34 EED59A5B-86F2-479D-BA1A-B8454E4D4F0F false https://play.acast.com/s/neuropsychopharmacologypodcast/foodaddiction-avalidconcept- 9d2ee34a-8828-4659-98dc-ca8e836ff6ea 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 foodaddiction-avalidconcept- Food Addiction: A Valid Concept? full

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]]> Sex Matters Sex Matters Tue, 15 Jan 2019 14:47:36 GMT 9:34 DDD59A5B-86F2-479D-BA1A-B8454E4D4F0F false https://play.acast.com/s/neuropsychopharmacologypodcast/sexmatters fcdc7d22-29fd-4a38-9c16-afcc245bb165 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 sexmatters Sex Matters full

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]]> Recent advances in the study of aggression Recent advances in the study of aggression Fri, 16 Nov 2018 14:47:36 GMT 9:34 CCD59A5B-86F2-479D-BA1A-B8454E4D4F0F false https://play.acast.com/s/neuropsychopharmacologypodcast/recentadvancesinthestudyofaggression f95bf043-5faa-4df4-b22b-fd96acc9bfd4 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 recentadvancesinthestudyofaggression Recent advances in the study of aggression full

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]]> Neurocognitive effects of umami: association with eating behavior and food choice Neurocognitive effects of umami: association with eating behavior and food choice Fri, 14 Sep 2018 14:47:36 GMT 9:34 BBD59A5B-86F2-479D-BA1A-B8454E4D4F0F false https://play.acast.com/s/neuropsychopharmacologypodcast/neurocognitiveeffectsofumami-associationwitheatingbehaviorandfoodchoice 159e18eb-c629-4a6e-972a-b1a6c9bdb301 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 neurocognitiveeffectsofumami-associationwitheatingbehaviorandfoodchoice Neurocognitive effects of umami: association with eating behavior and food choice full

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]]> Burst activation of dopamine neurons produces prolonged post-burst availability of actively released dopamine. Burst activation of dopamine neurons produces prolonged post-burst availability of actively released dopamine. Fri, 13 Jul 2018 14:47:36 GMT 9:34 AAD59A5B-86F2-479D-BA1A-B8454E4D4F0F false https://play.acast.com/s/neuropsychopharmacologypodcast/burstactivationofdopamineneuronsproducesprolongedpost-burstavailabilityofactivelyreleaseddopamine- 00a52bb6-f721-4b59-865d-4518b0157f8b 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 burstactivationofdopamineneuronsproducesprolongedpost-burstavailabilityofactivelyreleaseddopamine- Burst activation of dopamine neurons produces prolonged post-burst availability of actively released dopamine full

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]]> Debating the Persistence of Neurogenesis in Humans Debating the Persistence of Neurogenesis in Humans Thu, 24 May 2018 14:47:36 GMT 9:34 1ED59A5B-86F2-479D-BA1A-B8454E4D4F0F false https://play.acast.com/s/neuropsychopharmacologypodcast/debatingthepersistenceofneurogenesisinhumans 5fa10f59-f4d7-440b-b343-2eee4ad19b30 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 debatingthepersistenceofneurogenesisinhumans Debating the Persistence of Neurogenesis in Humans full

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]]> Considerations for the Use of DREADDs in Behavioral Neuroscience Considerations for the Use of DREADDs in Behavioral Neuroscience Fri, 16 Mar 2018 13:27:23 GMT 9:18 7E69EE13-EE41-493C-829B-FE345D0A09A7 false https://play.acast.com/s/neuropsychopharmacologypodcast/considerationsfortheuseofdreaddsinbehavioralneuroscience 8f7859c6-dc93-445c-8b91-0fafccf332d9 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 considerationsfortheuseofdreaddsinbehavioralneuroscience Considerations for the Use of DREADDs in Behavioral Neuroscience full

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]]> Neuropsychopharmacology Reviews: Cannabis and Cannabinoids: From Synapse to Society Neuropsychopharmacology Reviews: Cannabis and Cannabinoids: From Synapse to Society Fri, 12 Jan 2018 14:55:56 GMT 9:39 108E3429-8D21-4E53-84A4-564C19C8BA88 false https://play.acast.com/s/neuropsychopharmacologypodcast/neuropsychopharmacologyreviews-cannabisandcannabinoids-fromsynapsetosociety 743409d2-0f8e-43dc-b4c3-51316419f001 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 neuropsychopharmacologyreviews-cannabisandcannabinoids-fromsynapsetosociety Neuropsychopharmacology Reviews: Cannabis and Cannabinoids: From Synapse to Society full

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]]> Opioid Release after High-Intensity Interval Training in Healthy Human Subjects Opioid Release after High-Intensity Interval Training in Healthy Human Subjects Fri, 10 Nov 2017 15:52:52 GMT 6:15 74F8FBA1-25D6-4F9B-BDF3-DAB33498AF49 false https://play.acast.com/s/neuropsychopharmacologypodcast/opioidreleaseafterhigh-intensityintervaltraininginhealthyhumansubjects 7cea07d4-fd6d-43a3-82b8-3d65d7f2a0dc 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 opioidreleaseafterhigh-intensityintervaltraininginhealthyhumansubjects Opioid Release after High-Intensity Interval Training in Healthy Human Subjects full

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]]> Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats Wed, 13 Sep 2017 16:00:00 GMT 8:18 85719669-64C1-46BB-8FAC-0ADAA702BD40 false https://play.acast.com/s/neuropsychopharmacologypodcast/opioidself-administrationisattenuatedbyearly-lifeexperienceandgenetherapyforanti-inflammatoryil-10inthenucleusaccumbensofmalerats 625ced6a-de45-4f40-994f-3d8b8265c4fe 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 opioidself-administrationisattenuatedbyearly-lifeexperienceandgenetherapyforanti-inflammatoryil-10inthenucleusaccumbensofmalerats Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats full

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]]> Beta-Adrenoceptor Blockade in the Basolateral Amygdala, But Not the Medial Prefrontal Cortex, Rescues the Immediate Extinction Deficit Beta-Adrenoceptor Blockade in the Basolateral Amygdala, But Not the Medial Prefrontal Cortex, Rescues the Immediate Extinction Deficit Thu, 13 Jul 2017 14:37:37 GMT 8:47 FE796548-AB68-4E9B-B83C-51D683C28527 false https://play.acast.com/s/neuropsychopharmacologypodcast/beta-adrenoceptorblockadeinthebasolateralamygdala-butnotthemedialprefrontalcortex-rescuestheimmediateextinctiondeficit abeb29b3-a0ca-4fa8-a515-2a792e07a310 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 beta-adrenoceptorblockadeinthebasolateralamygdala-butnotthemedialprefrontalcortex-rescuestheimmediateextinctiondeficit Beta-Adrenoceptor Blockade in the Basolateral Amygdala, But Not the Medial Prefrontal Cortex, Rescues the Immediate Extinction Deficit full

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]]> Arbaclofen in Children and Adolescents with Autism Spectrum Disorder Arbaclofen in Children and Adolescents with Autism Spectrum Disorder Fri, 12 May 2017 13:31:02 GMT 9:36 BAC78FA1-DB8D-4C75-AF9D-F0A30565D125 false https://play.acast.com/s/neuropsychopharmacologypodcast/arbaclofeninchildrenandadolescentswithautismspectrumdisorder 5b898a37-550c-4048-85e4-403abbe3db10 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 arbaclofeninchildrenandadolescentswithautismspectrumdisorder Arbaclofen in Children and Adolescents with Autism Spectrum Disorder full

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]]> The Gateway Hypothesis of Addiction The Gateway Hypothesis of Addiction Wed, 15 Mar 2017 14:13:04 GMT 8:47 A2376801-DF7F-4267-B889-C94E5CF97856 false https://play.acast.com/s/neuropsychopharmacologypodcast/thegatewayhypothesisofaddiction 340dc6b0-1196-4de3-8429-c422cff1f288 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 thegatewayhypothesisofaddiction The Gateway Hypothesis of Addiction full

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]]> Sex as a Biological Variable: Who, What, When, Why, and How Sex as a Biological Variable: Who, What, When, Why, and How Thu, 12 Jan 2017 14:11:28 GMT 9:41 29D48D10-64CD-4613-81E6-551D39200565 false https://play.acast.com/s/neuropsychopharmacologypodcast/sexasabiologicalvariable-who-what-when-why-andhow d2192062-beac-4f89-b3ce-aef53805f9a7 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 sexasabiologicalvariable-who-what-when-why-andhow Sex as a Biological Variable: Who, What, When, Why, and How full

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]]> Neuropsychopharmacology Reviews: The Immunology of Behavior - Exploring the Role of the Immune System in Brain Health and Illness Neuropsychopharmacology Reviews: The Immunology of Behavior - Exploring the Role of the Immune System in Brain Health and Illness Fri, 02 Dec 2016 14:07:48 GMT 9:47 AAEF5BE7-E5D3-4B38-8CA8-07C7429E6D67 false https://play.acast.com/s/neuropsychopharmacologypodcast/neuropsychopharmacologyreviews-theimmunologyofbehavior-exploringtheroleoftheimmunesysteminbrainhealthandillness d93edd9e-89dc-4833-85cc-b16d410d6930 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 neuropsychopharmacologyreviews-theimmunologyofbehavior-exploringtheroleoftheimmunesysteminbrainhealthandillness Neuropsychopharmacology Reviews: The Immunology of Behavior - Exploring the Role of the Immune System in Brain Health and Illness full

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]]> LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality Fri, 07 Oct 2016 18:00:00 GMT 9:58 17DC7C30-365E-4CB6-9B14-E84931C07543 false https://play.acast.com/s/neuropsychopharmacologypodcast/lsdacutelyimpairsfearrecognitionandenhancesemotionalempathyandsociality e544ebaf-c2f4-44a5-841c-fe874191886f 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 lsdacutelyimpairsfearrecognitionandenhancesemotionalempathyandsociality LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality full

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]]> Harnessing Smartphone-Based Digital Phenotyping to Enhance Behavioral and Mental Health Harnessing Smartphone-Based Digital Phenotyping to Enhance Behavioral and Mental Health Thu, 12 May 2016 15:00:00 GMT 9:01 E6DDF030-8ED9-4EA2-A45F-59E3F3D5B60B false https://play.acast.com/s/neuropsychopharmacologypodcast/harnessingsmartphone-baseddigitalphenotypingtoenhancebehavioralandmentalhealth b5d8978b-48c0-4e5e-9c2d-bb08f1513161 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 harnessingsmartphone-baseddigitalphenotypingtoenhancebehavioralandmentalhealth Harnessing Smartphone-Based Digital Phenotyping to Enhance Behavioral and Mental Health full

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]]> Women at the Podium: ACNP Strives to Reach Speaker Gender Equality at the Annual Meeting Women at the Podium: ACNP Strives to Reach Speaker Gender Equality at the Annual Meeting Mon, 21 Mar 2016 14:47:36 GMT 9:34 1ED59A5B-86F2-479D-BA1A-B8454E4D4F0F false https://play.acast.com/s/neuropsychopharmacologypodcast/womenatthepodium-acnpstrivestoreachspeakergenderequalityattheannualmeeting 3c44e0b2-e8d9-470f-94fe-c54134e798db 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 womenatthepodium-acnpstrivestoreachspeakergenderequalityattheannualmeeting Women at the Podium: ACNP Strives to Reach Speaker Gender Equality at the Annual Meeting full

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]]> Abuse of New Psychoactive Substances: Threats and Solutions Abuse of New Psychoactive Substances: Threats and Solutions Tue, 09 Feb 2016 15:31:31 GMT 10:21 E253CB1D-CAC2-4FC1-B1C6-8E315906BD84 false https://play.acast.com/s/neuropsychopharmacologypodcast/abuseofnewpsychoactivesubstances-threatsandsolutions edde7fe7-25d8-4d39-a873-03f91b4b01f9 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 abuseofnewpsychoactivesubstances-threatsandsolutions Abuse of New Psychoactive Substances: Threats and Solutions full

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]]> Does Cannabis Cause, Exacerbate or Ameliorate Psychiatric Disorders? An Oversimplified Debate Discussed Does Cannabis Cause, Exacerbate or Ameliorate Psychiatric Disorders? An Oversimplified Debate Discussed Tue, 12 Jan 2016 15:00:18 GMT 10:21 384F69EF-CA28-4834-95E6-762102631AE2 false https://play.acast.com/s/neuropsychopharmacologypodcast/doescannabiscause-exacerbateoramelioratepsychiatricdisorders-anoversimplifieddebatediscussed e1d0f9af-2355-4223-878e-2cac87451832 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 doescannabiscause-exacerbateoramelioratepsychiatricdisorders-anoversimplifieddebatediscussed Does Cannabis Cause, Exacerbate or Ameliorate Psychiatric Disorders? An Oversimplified Debate Discussed full

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]]> Neuropsychopharmacology Reviews: Impact of Stress on the Brain: Pathology, Treatment and Prevention Neuropsychopharmacology Reviews: Impact of Stress on the Brain: Pathology, Treatment and Prevention Thu, 10 Dec 2015 15:29:31 GMT 10:55 F46B6166-B052-4855-8CCC-95517589EEB6 false https://play.acast.com/s/neuropsychopharmacologypodcast/neuropsychopharmacologyreviews-impactofstressonthebrain-pathology-treatmentandprevention b5c5b7d4-6449-4955-82f8-6efcbe763693 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 neuropsychopharmacologyreviews-impactofstressonthebrain-pathology-treatmentandprevention Neuropsychopharmacology Reviews: Impact of Stress on the Brain: Pathology, Treatment and Prevention full

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]]> Neuropsychopharmacology Reviews: Neurodevelopment and the Origins of Brain Disorders Neuropsychopharmacology Reviews: Neurodevelopment and the Origins of Brain Disorders Mon, 08 Dec 2014 15:30:00 GMT 10:03 E45EB9C4-CD4F-4DD6-88FA-33F1CD29AA05 false https://play.acast.com/s/neuropsychopharmacologypodcast/neuropsychopharmacologyreviews-neurodevelopmentandtheoriginsofbraindisorders d1b1176b-7c94-43cc-9fac-3f7660160287 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 neuropsychopharmacologyreviews-neurodevelopmentandtheoriginsofbraindisorders Neuropsychopharmacology Reviews: Neurodevelopment and the Origins of Brain Disorders full Neuropsychopharmacology Reviews, entitled Neurodevelopment and the Origins of Brain Disorders, subject discipline experts provide both experimental highlights and perspectives on the current understanding of basic mechanisms of neurodevelopment, the influence of developmental disruptions on childhood and adult-onset brain and behavioral disorders, and the emerging promise of translation into treatments.

In this podcast, the editors of this year's volume, Pat Levitt (Simms/Mann Chair in Development Neurogenetics, Children's Hospital Los Angeles) and Jeremy Veenstra-VanderWeele (Mortimer D Sackler Associate Professor of Psychiatry, Columbia University/New York State Psychiatric Institute), discuss the recent research and its future applications.

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]]> Neuropsychopharmacology Reviews, entitled Neurodevelopment and the Origins of Brain Disorders, subject discipline experts provide both experimental highlights and perspectives on the current understanding of basic mechanisms of neurodevelopment, the influence of developmental disruptions on childhood and adult-onset brain and behavioral disorders, and the emerging promise of translation into treatments.

In this podcast, the editors of this year's volume, Pat Levitt (Simms/Mann Chair in Development Neurogenetics, Children's Hospital Los Angeles) and Jeremy Veenstra-VanderWeele (Mortimer D Sackler Associate Professor of Psychiatry, Columbia University/New York State Psychiatric Institute), discuss the recent research and its future applications.

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]]> Caffeine consumption in adolescents Caffeine consumption in adolescents Mon, 08 Dec 2014 15:30:00 GMT 6:39 B951A266-EF5E-4EE4-B373-4539070203DF false https://play.acast.com/s/neuropsychopharmacologypodcast/caffeineconsumptioninadolescents 05d7d020-6eec-4af8-b10e-38b22ff20144 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 caffeineconsumptioninadolescents Caffeine consumption in adolescents full

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]]> The value of alcohol The value of alcohol Mon, 03 Mar 2014 15:00:00 GMT 26:51 24E2BB9E-5F5B-4505-A846-B0E5DB50AA59 false https://play.acast.com/s/neuropsychopharmacologypodcast/thevalueofalcohol 90b84bf7-027b-40d4-8295-cfd8cb87a1fc 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 thevalueofalcohol The value of alcohol full

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]]> Brain changes in young smokers Brain changes in young smokers Mon, 03 Mar 2014 15:00:00 GMT 26:51 24E2BB9E-5F5B-4505-A846-B0E5DB50AA59 false https://play.acast.com/s/neuropsychopharmacologypodcast/brainchangesinyoungsmokers a58e2cbe-e47e-4b78-af99-c155712c274c 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 brainchangesinyoungsmokers Brain changes in young smokers full Neuropsychopharmacology, Dr. Edythe London and colleagues took smoking histories, assessed cigarette craving and dependence, and examined the insula using magnetic resonance imaging (MRI) in 16-22-year-old participants. The results suggest that participants with greater smoking exposure had more severe nicotine dependence, more cigarette craving, and less insular thickness than those with less exposure.

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]]> Neuropsychopharmacology, Dr. Edythe London and colleagues took smoking histories, assessed cigarette craving and dependence, and examined the insula using magnetic resonance imaging (MRI) in 16-22-year-old participants. The results suggest that participants with greater smoking exposure had more severe nicotine dependence, more cigarette craving, and less insular thickness than those with less exposure.

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]]> Neuropsychopharmacology Reviews: Biomolecular Discovery: Mechanisms, Therapeutics, and Biomarkers in Neural Disorders Neuropsychopharmacology Reviews: Biomolecular Discovery: Mechanisms, Therapeutics, and Biomarkers in Neural Disorders Mon, 09 Dec 2013 15:00:00 GMT 26:51 24E2BB9E-5F5B-4505-A846-B0E5DB50AA59 false https://play.acast.com/s/neuropsychopharmacologypodcast/neuropsychopharmacologyreviews-biomoleculardiscovery-mechanisms-therapeutics-andbiomarkersinneuraldisorders ffa00b2c-83a0-4da5-b39d-b63440a4039d 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 neuropsychopharmacologyreviews-biomoleculardiscovery-mechanisms-therapeutics-andbiomarkersinneuraldisorders Neuropsychopharmacology Reviews: Biomolecular Discovery: Mechanisms, Therapeutics, and Biomarkers in Neural Disorders full

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]]> Smoking throughout pregnancy may contribute to emotional problems in children Smoking throughout pregnancy may contribute to emotional problems in children Mon, 07 Oct 2013 15:00:00 GMT 26:51 24E2BB9E-5F5B-4505-A846-B0E5DB50AA59 false https://play.acast.com/s/neuropsychopharmacologypodcast/smokingthroughoutpregnancymaycontributetoemotionalproblemsinchildren ff31a6d6-9e93-4f22-a8a2-a68e26e36c24 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 smokingthroughoutpregnancymaycontributetoemotionalproblemsinchildren Smoking throughout pregnancy may contribute to emotional problems in children full

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]]> HIV infection may raise risk of cocaine abuse HIV infection may raise risk of cocaine abuse Thu, 15 Aug 2013 15:00:00 GMT 26:51 24E2BB9E-5F5B-4505-A846-B0E5DB50AA59 false https://play.acast.com/s/neuropsychopharmacologypodcast/hivinfectionmayraiseriskofcocaineabuse 0a3f6d7f-c943-41b5-ac9d-36e6302958b1 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 hivinfectionmayraiseriskofcocaineabuse HIV infection may raise risk of cocaine abuse full

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]]> A taste of alcohol A taste of alcohol Mon, 20 May 2013 15:00:00 GMT 26:51 24E2BB9E-5F5B-4505-A846-B0E5DB50AA59 false https://play.acast.com/s/neuropsychopharmacologypodcast/atasteofalcohol 5500bbbd-bd23-4b7f-813e-4dbfa0a185e1 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 atasteofalcohol A taste of alcohol full

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]]> Neuropsychopharmacology Reviews: Epigenetics Neuropsychopharmacology Reviews: Epigenetics Fri, 30 Nov 2012 15:00:00 GMT 26:51 24E2BB9E-5F5B-4505-A846-B0E5DB50AA59 false https://play.acast.com/s/neuropsychopharmacologypodcast/neuropsychopharmacologyreviews-epigenetics 645811d5-3790-4b3a-891b-d17061788e40 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 neuropsychopharmacologyreviews-epigenetics Neuropsychopharmacology Reviews: Epigenetics full

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]]> Bath salts Bath salts Fri, 21 Sep 2012 15:00:00 GMT 26:51 24E2BB9E-5F5B-4505-A846-B0E5DB50AA59 false https://play.acast.com/s/neuropsychopharmacologypodcast/bathsalts 4cec4337-4a7c-4c1e-b2ab-d4bd6a099875 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 bathsalts Bath salts full

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]]> Neuropsychopharmacology Reviews: Neurotherapeutics Neuropsychopharmacology Reviews: Neurotherapeutics Wed, 18 Jan 2012 15:00:00 GMT 26:51 24E2BB9E-5F5B-4505-A846-B0E5DB50AA59 false https://play.acast.com/s/neuropsychopharmacologypodcast/neuropsychopharmacologyreviews-neurotherapeutics 6d8bd9c4-9730-42dc-8cf9-67ccba5e29f6 1b454f3a-002e-540e-82a0-3e5bcb0b5da9 neuropsychopharmacologyreviews-neurotherapeutics Neuropsychopharmacology Reviews: Neurotherapeutics full

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