In this episode, Sapient’s Tanya Nguen joins us to bring a unique perspective that transcends traditional boundaries, offering valuable insights into treating clinical human diseases. Tanya Nguyen shares insights from her college research in neuroscience, exploring the formative years that shaped her journey. Discover the profound influence of clinical experiences on Tanya's approach to research and how Sapient has provided the opportunity to contribute to science at various stages of drug development.

0:51: The transition from a "non-Omics" background to shaping the future of clinical disease treatment

2:19: Impact of her college research in neuroscience during her formative years

6:13: Connecting research and clinical outcomes: Sapient's role in all stages of drug development 

7:29: Tanya shares her "OMG moment" that set her on the path of scientific exploration

9:02: Significant of mass spectrometry on in the broad Omics field, spanning from early-stage discovery to patient-oriented applications

10:51 - The pivotal role Omics plays at Sapient and the exciting metrics and stats the organization utilizes

13:06 - The future of Omics at Sapient, focusing on ramping up metabolomics, lipidomics, and proteomics to make a lasting impact beyond the genome

18:05 - A glimpse into a day at Sapient and the unique Sapient approach

19:39 🍹 Bonus Content: Discover Tanya’s hobby outside the lab

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Thank you for joining us for an exciting year of omgOMX! We're wrapping up 2023 with Bruker's Pharma Biopharma lead, Mike Greig, who shares his incredible journey from a chemistry major to the world of mass spec. 

Join us as he reminisces on:

00:28: Early Days: From polymers (nail polish anyone?) to discovering the magic of mass spec in the pharma industry 

04:39: Influential People: Those who shaped his career and inspired him along the way 

06:47: Mike's OMG Moment: A candied story just in time for Christmas! 

08:07: Drug Discovery Advancements: A glimpse into the ever-evolving landscape 

10:17: The Drug Discovery Pipeline: How it has transformed over time 

12:48: Mass Spec's Crucial Role: How this technology drives innovation in drug discovery 

14:41: Challenges and Solutions: Overcoming obstacles in the pharma biopharma industry 

16:31: Mass Spec Innovation Pipeline: A peek into the future of this powerful technology 

18:42: Getting Up and Running: How mass spec companies help researchers and scientists succeed 

20:29: The Sports Influence: An unexpected connection that inspires 

Don't miss this special episode packed with insights and inspiration!

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Don't miss this inspiring episode that showcases the power of women in science and the potential of immunopeptidomics to shape the future of cancer therapies. Hit that subscribe button and share this episode with fellow science enthusiasts!

00:21 - Nicola's humble beginnings in virology, shaping her path to where she is today

05:48 - Moving to the UK and her exposure to mass spectrometry at Benedict Kessler's proteomics facility

07:43 - Working on HIV vaccines with experts to understand how infected cells appear to the immune system

09:02 - Specializing in profiling immune molecules in diseases and cancer to inform vaccine development

10:00 - The breakthrough realization of applying immune system knowledge to cancer research

10:18 - Focusing on mechanistic research and profiling specific antigens for potential clinical applications

11:29 - Collaboration with industry for cancer therapies and the importance of automation in research

13:09 - Automating the process for analyzing broader sample cohorts and optimizing sample acquisition

14:42 - The challenge of high-throughput analysis and the future of immunopeptidomics

16:38 - The significance of validation in mass spectrometry workflows and antigen identification

21:15 - The impact of the pandemic on vaccine research and its role in cancer therapy

23:53 - Optimism about future advancements in immunopeptidomics and cancer immunotherapy

27:56 - Surprising discoveries and expanding collaborations in industry and clinical partnerships

30:32 - Balancing personal and professional life as an academic researcher

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Hit the notification button and subscribe to our channel for updates on future episodes and more exciting insights into the fun world of science.

00:36 - Exploring the Humble Beginnings of Nikolai Slavov

10:00 - Discovering His Spin-off Nonprofit, Focused Research Organization (FRO), and Parallel Squared Technology Institute (PTI) to Accelerate Proteome Biology Research

15:03 - Handling Massive Data and Information to Make Scientific Discoveries

19:20 – PTI's Mission and How Mass Spectrometry Influences the Single-Cell Proteomics Space

25:16 - Nikola's "OMG" Moment that Catapulted Him into the World of Science

26:23 – The Power of Mathematics 

28:34 - Nikola's Perspective and Drive to Make Meaningful Contributions to Science

31:28 - A Shoutout to the Incredible Team Behind the Scenes

YouTube: @NikolaiSlavovResearch  

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00:39 - Introduction: Pelle's diverse background, from analytical chemistry to 3D printing, electrical engineering to how he joined Enveda Biosciences 

03:18 - Pelle's "OMG" moment: How he got started in natural products drug discovery

05:25 - The significance of Enveda Biosciences within the natural products landscape

07:44 - The role of mass spectrometry and high-throughput screening in drug discovery

11:03 - The diverse sample sources of medicinal plants for research and how Enveda Biosciences expands their library

12:10 - The humble beginnings of Enveda Biosciences: : The CEO's personal experience with herbal medicine and the potential of natural products

13:28 - How Pelle's educational and experiential background influences his work and shaped his approach to industrializing natural products drug discovery.

18:04 - The parallels and differences between academia and industry, and how Enveda Biosciences combines the best of both worlds

19:35 - The art of balancing diverse projects

20:40 - Overcoming innovation blocks, staying inspired and refocused

21:54 - Enveda's strategy of internalizing various aspects natural products space, and what other factors are needed for long-term success

23:48 – 3D printing skills showdown: Kate's timsTOF SCP vs. Pelle's student's ubiquitin protein structure.

Connect with Pelle Simpson on LinkedIn

Explore Enveda Biosciences

Don't forget to like, share, and subscribe for the latest episodes of omg OMx, where we humanize science and get inspired by scientists around the globe.

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00:27: Balyn's journey from organic chemistry to chemical biologist, leading to the establishment of Zaro Lab at UCSF

03:32: The influential figures people shaped Balyn's career and provided support along the way.

05:10: The influence of San Francisco's vibrant ecosystem has played on Balyn's ability as a mentor and a scientist.

07:05: Balyn's groundbreaking "omg" moment in mass spectrometry, when her first chemical probe yielded remarkable insights into protein modification.

08:34: The significance of mass spectrometry for biologists and its importance in in advancing scientific research.

10:09: Challenges Balyn faced in the field of mass spectrometry and the innovative tools she used to overcome them.

12:12: Balyn's hopes for advancements in sample preparation technologies such as PreOmics kits and PepSep columns.

14:47: Critical discoveries in innate immunity research, particularly the decision-making processes of macrophages.

16:30: Anticipated breakthroughs and advancements that will shape the next decade of innate immunity research.

19:19: The challenges and intricacies of working with small and precious samples, where microgram quantities can have a significant impact depending on the cell type.

20:27: The importance of incorporating biological knowledge and expertise in method development and experiment training, beyond sample preparation.

20:47: Balyn’s exciting experiments and memorable samples that have fueled her scientific pursuits.

24:13 - Valuable advice on building a fulfilling and successful career, empowering aspiring scientists to navigate their own path with confidence.

26:34 - In Balyn's closing message, experience the joy and fulfillment of working on intriguing projects and the freedom to pursue one's passions within the scientific realm.

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In this episode of omg OMx, Bruker's science-driven podcast, Kate Stumpo interviews Daniel Hornburg, the VP of Proteomics at Seer, as they discuss the innovative technologies in plasma proteomics. From nanoparticle-based enrichment to mass spec refinements, they explore how these tools facilitate unbiased, deep, and rapid proteomics. Join the discussion and stay updated on the latest advancements in #plasmaproteomics and #proteomicstechnologies.

00:41 From Start-Up to Proteomics: Daniel's Journey

04:21 Advice for Ph.D. Students Interested in Scientific Problems

07:03 Turning Failure into Success

09:21 Harnessing Those "Omg" Eureka Moments — When Things Come Together 

12:28 Seer's Unique Approach to Plasma Proteomics

17:16 Implications of Seer's Technology for Human Health

20:01 Handling Large Volumes of Data in Proteomics Through Bioinformatics

22:19 Longitudinal Studies in Plasma Proteomics 

24:12 Challenges Beyond Proteins, PTMs

26:13 Keeping an Eye for Seer's Innovations

28:21 Behind Winning Awards and Recognition 

29:59 NASA Story Showdown - Daniel Vs Kate

Now that you've watched the episode, we want to hear from you! Who has the more exciting NASA story- Kate or Daniel? Would you rather be the analysis scientist or the zero-gravity scientist?

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Help Michael support his team's scientific endeavors. Share your suggestions on how they can make money in the comments section below.

0:54: Michael Girgis' Journey to Today

1:44: Delving into the World of Lipid Nanoparticles (LNP) Research

2:49: Understanding the Significance of LNP and How They Work

6:45: Real-World Applications of LNP in mRNA Delivery

11:53: Michael Girgis' Fascinating "OMG" Moments as a Developing Scientist

14:16: Exploring Mass Spectrometry and Different Methodologies

15:01: The Importance of Mass Spec for LNP Characterization and Favorite Methods

20:02: Success Beyond Tools: Overcoming Challenges in Science

22:35: Channeling Passion for Science and Curiosity

25:09: Staying Connected in the Lab with Advanced Instrumentation

28:10: Keeping the Science Journey Going: Michael Girgis' Future Goals

30:36: Michael's Wisdom and Insights for Aspiring Scientists

Subscribe to the podcast for updates on future episodes.

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omg OMx mission is to make science simple and tangible for our viewers. So, get ready for a fascinating conversation that will inspire and inform you. Remember to subscribe to our channel and hit the notification bell to stay updated on our latest episodes!

1:00 From Humble Beginnings to Scientific Success: Ramon's Inspiring Journey

2:28 How Ramon Balances Family, Work, and Life: Lessons Learned

4:58 Learning from the Best: Ramon's Mentoring and Knowledge-Sharing Tips

9:02 Innovating Science: Ramon's Trailblazing Journey through Multiple Companies

13:35 Mass Spectrometry: The Key to the Future of Spatial Biology

17:04 The Power of Artificial Intelligence in Research: Ramon's Insights

22:26 Fueling Curiosity: Inspiring People and Ideas According to Ramon

26:37 Cutting-Edge Technology to Revolutionize Spatial Metabolomics: Ramon's Watchlist

34:17 Join the Search for Ramon's Lab Mascot: Help us Find the Perfect Fit!

Discover more omg science moments with omg OMx, Bruker's science-driven podcast. 

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In this episode, Kate Stumpo is joined by Rohan Thakur, President of Life Science Mass Spectrometry at Bruker.

0:00 – Start

2:50 – Championing a disruptive product, Trapped Ion Mobility Spectrometry (TIMS) 

5:35 – Making an impact in plasma proteomics through a complete ecosystem 

7:36 – Learning and working with trailblazers to design better technology 

8:52 – Rohan’s omg moment on how Bruker impacted a field 

10:16 – Listening to key opinion leaders (KOL) to drive spatial omics

12:31 – Rohan on his omg “science crush.” 

13:22 – Audience question: Who’s the next omg person in cancer oncology and biology?

14:05 – Empathic Design helping solve customer problems 

15:20 – Tying features to benefit from bringing to the user to help them solve their problem 

16:45 – Translating complex technology into new and different markets and solving difficult problems while bringing them mainstream 

19:03 – Keeping science disruptive, challenging the status quo, and moving outside comfort zones

21:37 – Moving past labels and titles, we “rent” let’s have fun and drive science with the tools we develop 

24:16 – Rohan shares his first encounter with mass spectrometry and its appeal

25:46 – Whom will Rohan be if he goes as “undercover boss”? 

27:07 – The joy of a customer’s “Eureka” omg moment

29:13 – Audience question: What’s your omg science moment?

29:19 – Kate shares her omg moment of her own

Discover more omg science moments with omg OMx, Bruker’s science-driven Podcast.

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