Forum

Wearables Roundtable: Bao and Rogers

Tue, 02 Sep 2025 09:00:00 GMT

Clinical grade electronic wearable technology today can be flexible, stretchable, and skin-like, as researchers have developed materials that can help electronics interface with your body. Chief Editor Barbara Cheifet speaks with Drs. Zhenan Bao and John Rogers about the many devices that they are working on – from health monitoring in neonates to smart bandages for wounds – and how they will complement and advance global health.

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Photoacoustic Imaging Roundtable: Ntziachristos and Yao

Tue, 19 Aug 2025 09:00:00 GMT

Photoacoustic imaging, or optoacoustic imaging, combines both optical imaging and ultrasound technology to generate high-resolution images of biological tissues. Chief Editor Barbara Cheifet speaks with Drs. Vasilis Ntziachristos and Junjie Yao about how photoacoustic imaging, developed back in the 1970s, is now moving towards translational applications such as diagnostics and disease monitoring.

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Biomolecular Ultrasound Roundtable: Maresca and Shapiro

Tue, 05 Aug 2025 10:00:00 GMT

Biomolecular ultrasound is an exciting technology that uses sound waves to visualize tissues within the body. Chief Editor Barbara Cheifet speaks with Drs. David Maresca and Mikhail Shapiro about using ultrasound for imaging and also how the technology is being used to drive the transport of engineered molecules across cellular membranes for a wide range of applications. This includes their recent work mentioned in the episode https://doi.org/10.1126/science.ads1325 and https://www.science.org/doi/abs/10.1126/science.adt0293

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Foundation Models Roundtable: Lopez and Hie

Tue, 22 Jul 2025 10:00:00 GMT

Foundation models are machine learning models trained on large datasets and applicable for a wide range of use cases. Chief Editor Barbara Cheifet speaks with Drs. Brian Hie and Marie Lopez about how these models are being used for analysis of the function and structure of DNA, RNA, and proteins, and how they are being developed for clinical use.

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From Bench to Podcast: Ali Shaib

Thu, 03 Oct 2024 14:16:01 GMT

In this episode, Associate Editor Cláudia Vilhena sits down with Ali Shaib, the lead author of an exciting new study showcasing expansion microscopy and the visualization of individual protein shapes, using standard laboratory microscopes.

Tune in as Ali and Cláudia explore the “accidental” origins of the study, the importance of mentorship and collaboration, and the democratization of super-resolution methods.

If you're curious about the intersection of super-resolution microscopy and clinical applications, this is an episode you won’t want to miss!

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From Bench to Podcast: Chloe Fishman

Mon, 23 Sep 2024 13:17:17 GMT

On this episode, our Associate Editor Cláudia Vilhena interviews Chloe Fishman, the first author of a great story on a new and versatile tool using recombitrons for bacteriophage gene editing.

Join us as Cláudia and Chloe touch bases on the advantages of this tool over existing methods, discuss the relevance of phage therapy on the fight against antimicrobial resistance and share their thoughts on the crucial role mentorship plays in empowering early career researchers.

If you are interested in phage therapy and astrobiology, then this episode is for you!

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From Bench to Podcast: Nicoletta Cieri

Tue, 20 Aug 2024 14:03:18 GMT

On this episode, our Associate Editor Cláudia Vilhena interviews Nicoletta Cieri, the first author of a great story on how a devised analytic framework can aid the prevention of post-transplant disease recurrence.

Join us as Nicoletta and Cláudia explore the highlights of the story, discuss the future of individualized medicine and touch-bases on future career opportunities following the postdoc phase.

If you are interested in anti-tumor responses and personalized medicine, then this episode is for you!

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Organoids Roundtable: Lancaster and Pasca

Wed, 26 Jun 2024 09:00:56 GMT

In this episode of Forum, Chief Editor Barbara Cheifet speaks with Madeline Lancaster and Sergiu Pasca about organoids – cell cultures derived from stem cells and crafted to replicate a particular organ or certain cell types that make up an organ. These two experts in the field discuss neural organoids specifically, and how they are being used to study both basic biology of the brain and their future impacts on disease research.

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From Bench to Podcast: Sean Johnson

Fri, 14 Jun 2024 16:17:13 GMT

On this episode, our Associate Editor Cláudia Vilhena interviews Sean Johnson, the first author of a timely and great story on how to experimentally evaluate the performance of AI-generated enzymes.

Sean and Cláudia discussed the timely topic of AI for protein design and the implications for future research, and also touched base on how it was to transition from academia to industry.

For those who are interested in protein functionality, this episode is for you!

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From Bench to Podcast: Roman Sarrazin-Gendron

Thu, 06 Jun 2024 12:33:45 GMT

On this episode of From Bench to Podcast, our Associate Editor Cláudia Vilhena interviews Roman Sarrazin-Gendron, first author of an absolutely incredible story about...videogames!

During this informal chat, Roman and Cláudia talked about the behind the scenes of Boderlands Science. They explored the concepts of Citizen Science, Massively Multiplayer Online Video Games, and the impact of community work on gathering data about our microbiome.

For those that love microbiology and/or video games, and wish to know how these two worlds merge, this episode is for you!

Check out the trailer and spot the famous actress!

https://www.youtube.com/watch?v=L_mH6Ak_Ny0&t=5s

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Neurotech Roundtable: Anikeeva, Courtine, and Bloch

Wed, 15 May 2024 10:00:33 GMT

On this episode, Chief Editor Barbara Cheifet speaks with Polina Anikeeva from MIT, Grégoire Courtine from EPFL, and Jocelyn Bloch, a neurosurgeon at Lausanne University Hospital. These three leaders in the field of neurotechnologies discuss new devices that help us learn how our brain works, implantable brain-computer interfaces that are helping patients with neurological disorders walk again, and why this field is so exciting today.

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From Bench to Podcast: He, Jin and Shi

Wed, 01 May 2024 14:31:16 GMT

In this episode, our Associate Editor Cláudia Vilhena talks with three authors of the method Starfysh, a computational toolbox combining spatial transcriptomics and histology data.

During their chat, Siyu, Yinou and Lingling, all at different stages of their academic path, dig into the layers of Starfysh and its relevance for cancer research. They also share the struggles of peer review, the wonders of collaborative work and how this experience shaped their, sure-to-be fantastic, academic careers.

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From Bench to Podcast: Marcus Walker

Tue, 16 Apr 2024 13:07:42 GMT

On our very first episode of the new podcast series from Nature Biotechnology, our Associate Editor Cláudia Vilhena interviews Marcus Walker, first author of a fantastic story on engineered bacteria used to stain textiles.

With an informal and honest touch, Marcus and Cláudia dive into the behind the scenes of the paper. From the inspiration to combine microbiology and fashion, passing by what went wrong at the bench, all the way to the economical and environmental implications of living biomaterials.

For all those who struggle with measuring optical density, this episode is for you!

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Protein Design Roundtable: Deane and Grigoryan

Thu, 01 Feb 2024 10:15:00 GMT

For our special Focus Issue, Chief Editor Barbara Cheifet talks with Charlotte Deane and Gevorg Grigoryan about applying new machine learning methods to protein structure prediction and protein design. We discuss exciting new technologies and their current and future clinical applications.

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Super Resolution and Expansion Microscopy Roundtable: Boyden and Danzl

Thu, 29 Jun 2023 17:16:26 GMT

Microscopy methods today are enabling researchers to see small details within cells, previously undetectable by light microscopy. Chief Editor Barbara Cheifet speaks with Drs. Ed Boyden and Johann Danzl about the technological advances and challenges in the fields of super resolution and expansion microscopy.

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Single-cell metabolomics Roundtable: Alexandrov and Le

Wed, 26 Apr 2023 09:30:35 GMT

Single-cell metabolomics is focused on detecting, understanding, and interpreting metabolites and lipids at single-cell resolution. Theodore Alexandrov and Anne Le discuss recent technical advances in the field with Chief Editor Barbara Cheifet.

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Microbiome Roundtable: Fischbach and Mazmanian

Wed, 01 Mar 2023 10:30:53 GMT

Chief Editor Barbara Cheifet speaks with Drs. Michael Fischbach and Sarkis Mazmanian about recent work uncovering functional roles for our microbiomes and what is needed to bring microbiome therapies to the clinic.

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Xenotransplantation Roundtable: Locke and Sykes

Wed, 21 Dec 2022 10:30:52 GMT

Jayme Locke and Megan Sykes discuss advances in xenotransplantation with Chief Editor Barbara Cheifet, including details of the recent transplants of pig heart and kidney into braindead patients, as well as the questions researchers and clinicians are asking next.

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Human Cell Atlas Roundtable: Regev and Teichmann

Wed, 31 Aug 2022 09:00:04 GMT

Aviv Regev and Sarah Teichmann talk with Senior Editor Barbara Cheifet about the development and exciting recent progress of the Human Cell Atlas project.

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PROTACs Roundtable: Bertozzi and Deshaies

Mon, 18 Jul 2022 09:00:25 GMT

Senior Editor Markus Elsner has a discussion with Ray Deshaies and Carolyn Bertozzi about PROTACs, small molecules that have the potential to treat previously-undruggable targets in clinical applications.

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3D Genome Roundtable: Pombo and Phillips-Cremins

Mon, 16 May 2022 09:00:02 GMT

Ana Pombo and Jennifer Phillips-Cremins talk with senior editor Barbara Cheifet about how new methods to look at the 3D genome are providing insights into the links between genome structure and cellular function.

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CRISPR Screening Roundtable: Stegmaier and Doench

Wed, 06 Apr 2022 09:00:09 GMT

Kimberly Stegmaier and John Doench speak with senior editor Markus Elsner about the history and latest developments in the field of CRISPR screening.

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Drug Delivery Roundtable: Whitehead and Langer

Wed, 08 Dec 2021 10:00:00 GMT

Kathryn Whitehead and Robert Langer talk with Senior Editor Markus Elsner about drug delivery methods and their applications within a wide range of therapeutic modalities.

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Gene Therapy Roundtable: High and Kohn

Thu, 16 Sep 2021 09:00:00 GMT

Katherine High and Donald Kohn speak with senior editor Markus Elsner about the latest developments in gene therapy

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Hope Lies in Dreams Chapter 1

Wed, 08 Sep 2021 09:00:00 GMT

Stan Crooke is born ⬩ A tenuous existence ⬩ Life with his mother ⬩ The Tech Corner ⬩ Arsenal Tech High School ⬩ Nancy ⬩ Hoodlum ways ⬩ Off to Purdue

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Optogenetics Roundtable: Deisseroth and Gradinaru

Tue, 25 May 2021 09:00:00 GMT

Karl Deisseroth and Viviana Gradinaru speak with senior editor Markus Elsner about the current state of optogenetics and how it can be used to better understand and treat human disease.

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Precision Oncology Roundtable: Siu and Mardis

Wed, 10 Mar 2021 10:00:00 GMT

Lillian Siu and Elaine Mardis speak with senior editor Markus Elsner about the current state of precision cancer medicine and what progress the future might hold.

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The T cell wars

Tue, 24 Nov 2020 10:00:00 GMT

Nature Biotechnology’s Irene Jarchum speaks with Michel Sadelain about off-the-shelf CAR-T cells, and discusses a recent paper from Maksim Mamonkin’s group describing a clever strategy to mitigate CAR-T cell rejection. The paper was published in Nature Biotechnology and can be read here.

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CRISPR Roundtable: Liu and Doudna

Tue, 07 Jul 2020 09:00:00 GMT

David Liu and Jennifer Doudna talk with our Senior Editor Markus Elsner about the state of the genome editing field and what challenges remain, especially as various therapies are now entering the clinic. This episode is part of Nature Biotechnology’s Focus issue on CRISPR tools and therapies.

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Bioengineered scaffolds repair the uterus in rabbits

Wed, 01 Jul 2020 09:00:00 GMT

A recent Nature Biotechnology paper from Tony Atala and colleagues at Wake Forest describes the use of bioengineered scaffolds to repair substantial injuries to rabbit uteri, supporting pregnancies and live births. Senior Editor Irene Jarchum discusses this work with Mats Brännström and Mats Hellström, both from Gothenburg University in Sweden. You can read the paper here.

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Worms and gut microbes team up to kill corn pest

Tue, 05 May 2020 09:00:00 GMT

David Shapiro Ilan talks to Senior Editor Susan Jones about a paper in the May issue where Ricardo Machado and colleagues describe how bacterial symbionts of nematodes are evolved to help these worms kill a devastating crop pest: Western Corn Rootworm. The paper can be read here.

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First human trial of engineered T cells

Tue, 21 Apr 2020 09:00:00 GMT

Senior Editor Markus Elsner talks to Alex Marson of UCSF about the significance of a Science paper describing the phase 1 clinical trial of CRISPR-engineered T cells. The work was carried out by Carl June and Edward Stadtmauer from UPenn. Read the paper here.

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Repurposing viral immunity to fight cancer

Wed, 26 Feb 2020 10:00:00 GMT

Senior editor Irene Jarchum talks to Cliona Rooney about a recent paper in which Mark Cobbold and colleagues describe an antibody-mediated strategy to re-target virus-specific T cells against tumors. The paper was published in Nature Biotechnology; it can be read here.

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Molecular mapping of tumor heterogeneity

Tue, 11 Feb 2020 10:00:00 GMT

Brady Huggett talks with Zemin Zhang about a recent Nature Biotechnology paper detailing the use of spatial transcriptomics in providing new insights into tumor architecture. The work was done by Itai Yanai and co-authors, and the paper can be read here.

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Supercooling extends human liver storage

Tue, 14 Jan 2020 10:00:00 GMT

Senior Editor Irene Jarchum talks to Stefan Schneeberger about the significance of a recent Nature Biotechnology paper describing a sophisticated perfusion machine to keep human livers alive for a week. The work was carried out by Pierre-Alain Clavien and colleagues from ETH Zurich. Read the paper here.

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