60 acast.com Hope Lies in Dreams https://www.nature.com/immersive/d41587-021-00015-5/index.html en Nature Biotechnology Stan Crooke rose from poverty to found a company that pioneered antisense drugs. After decades of struggle and years of public doubt, the company created a treatment that has saved thousands of children from the brutal disease spinal muscular atrophy.

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> false info+f42701bf-0587-40dc-b698-a09087aea74f@mg-eu.acast.com f42701bf-0587-40dc-b698-a09087aea74f hope-lies-in-dreams http://rss.acast.cloud/hope-lies-in-dreams serial https://assets.pippa.io/shows/62f26f5bca2a725a46f6e899/show-cover.jpg https://www.nature.com/immersive/d41587-021-00015-5/index.html Hope Lies in Dreams https://feeds.acast.com/public/shows/f42701bf-0587-40dc-b698-a09087aea74f Chapter 10: Dr. Crooke Chapter 10: Dr. Crooke Wed, 10 Nov 2021 10:00:00 GMT 50:53 3fc44d57-884c-457c-9770-d3f3edee4be3 false https://play.acast.com/s/hope-lies-in-dreams/chapter10-dr.crooke 3fc44d57-884c-457c-9770-d3f3edee4be3 f42701bf-0587-40dc-b698-a09087aea74f chapter10-dr.crooke The biggest deal ⬩ In the black ⬩ End of an era ⬩ n of 1 ⬩ Small places ⬩ A life of control ⬩ The doctor will see you now full 10

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> Chapter 9: the last of his kind Chapter 9: the last of his kind Wed, 03 Nov 2021 09:00:00 GMT 39:09 cb6a231d-4f33-446f-a144-39cf178ea941 false https://play.acast.com/s/hope-lies-in-dreams/chapter9-thelastofhiskind cb6a231d-4f33-446f-a144-39cf178ea941 f42701bf-0587-40dc-b698-a09087aea74f chapter9-thelastofhiskind Award season ⬩ NURTURE, and Gabriel ⬩ Kyle Derkowski’s new future ⬩ The drugs of SMA ⬩ Piece of magic ⬩ Frank’s Super Bowl full 9

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> Chapter 8: part of something big Chapter 8: part of something big Wed, 27 Oct 2021 09:00:00 GMT 42:23 f9cf2617-a7d6-4fc0-b8c4-83b4a42b52f9 false https://play.acast.com/s/hope-lies-in-dreams/chapter8-partofsomethingbig f9cf2617-a7d6-4fc0-b8c4-83b4a42b52f9 f42701bf-0587-40dc-b698-a09087aea74f chapter8-partofsomethingbig Ethics lessons ⬩ Biogen re-ups ⬩ The ultimate sacrifice ⬩ FDA as partner ⬩ Emma’s phase 3 ⬩ Doug Kerr’s bright idea ⬩ Isis to Ionis ⬩ Spinraza approval full 8

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> Chapter 7: the SMA gang Chapter 7: the SMA gang Wed, 20 Oct 2021 09:00:00 GMT 40:23 b282763e-608b-431d-934c-1cfcf3e29300 false https://play.acast.com/s/hope-lies-in-dreams/chapter7-thesmagang b282763e-608b-431d-934c-1cfcf3e29300 f42701bf-0587-40dc-b698-a09087aea74f chapter7-thesmagang The Larsons ⬩ The skunkworks project ⬩ The most unmet need ⬩ Instant synergy ⬩ Another first for antisense ⬩ The clinic, again ⬩ The achievements of Kathie Bishop full 7

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> Chapter 6: lone voice in the wilderness Chapter 6: lone voice in the wilderness Wed, 13 Oct 2021 09:00:00 GMT 43:12 d0f3f803-78ad-45a9-a7a6-d5a0542d1b90 false https://play.acast.com/s/hope-lies-in-dreams/chapter6-lonevoiceinthewilderness d0f3f803-78ad-45a9-a7a6-d5a0542d1b90 f42701bf-0587-40dc-b698-a09087aea74f chapter6-lonevoiceinthewilderness Rosanne saves the company ⬩ Ibis is sold ⬩ An approval ⬩ Souring on Genzyme ⬩ The end of Genta ⬩ The discovery of the SMA gene full 6

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> Chapter 5: valley of antisense Chapter 5: valley of antisense Wed, 06 Oct 2021 09:00:00 GMT 41:37 dcffa1f3-1843-4a46-902c-e6874905b807 false https://play.acast.com/s/hope-lies-in-dreams/chapter5-valleyofantisense dcffa1f3-1843-4a46-902c-e6874905b807 f42701bf-0587-40dc-b698-a09087aea74f chapter5-valleyofantisense The genomics bubble ⬩ Affinitak fails ⬩ Lynne saves the company ⬩ Hybridon pivots ⬩ New chemistries ⬩ Regulus formed ⬩ Isis as cult full 5

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> Chapter 4: three kinds of failure Chapter 4: three kinds of failure Wed, 29 Sep 2021 09:00:00 GMT 43:47 efcf269f-cad6-49e5-bb1a-1c3da1960a9c false https://play.acast.com/s/hope-lies-in-dreams/chapter4-threekindsoffailure efcf269f-cad6-49e5-bb1a-1c3da1960a9c f42701bf-0587-40dc-b698-a09087aea74f chapter4-threekindsoffailure Stumbling out of the gate ⬩ Launch of Vitravene ⬩ Questions about antisense ⬩ The field thins ⬩ Clinical failure ⬩ The darkest days full 4

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> Chapter 3: San Diego restart Chapter 3: San Diego restart Wed, 22 Sep 2021 09:00:00 GMT 47:35 30fa98e3-d282-45ef-91ab-70c784877c78 false https://play.acast.com/s/hope-lies-in-dreams/chapter3-sandiegorestart 30fa98e3-d282-45ef-91ab-70c784877c78 f42701bf-0587-40dc-b698-a09087aea74f chapter3-sandiegorestart Rosanne ⬩ An investor emerges ⬩ Founding Isis ⬩ The old garage ⬩ A proper space ⬩ A growing antisense scene ⬩ Starting a pipeline ⬩ Isis goes public full 3

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> Chapter 2: a winding path Chapter 2: a winding path Wed, 15 Sep 2021 09:00:00 GMT 46:37 3412c62d-d5b4-4137-a21a-df8091c50f94 false https://play.acast.com/s/hope-lies-in-dreams/chapter2-awindingpath 3412c62d-d5b4-4137-a21a-df8091c50f94 f42701bf-0587-40dc-b698-a09087aea74f chapter2-awindingpath Quits Purdue ⬩ Pharmacy school ⬩ Off to Baylor ⬩ Harris Busch ⬩ Bristol Labs ⬩ SmithKline ⬩ The death of Nancy Crooke ⬩ The end of SmithKline full 2

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> Chapter 1: an ugly place Chapter 1: an ugly place Wed, 08 Sep 2021 09:00:00 GMT 32:02 dac3cd70-0d95-4de5-8702-5a290f4f6c9f false https://play.acast.com/s/hope-lies-in-dreams/chapter1-anuglyplace dac3cd70-0d95-4de5-8702-5a290f4f6c9f f42701bf-0587-40dc-b698-a09087aea74f chapter1-anuglyplace Stan Crooke is born ⬩ A tenuous existence ⬩ Life with his mother ⬩ The Tech Corner ⬩ Arsenal Tech High School ⬩ Nancy ⬩ Hoodlum ways ⬩ Off to Purdue full 1

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]> Hope Lies in Dreams trailer Hope Lies in Dreams trailer Wed, 01 Sep 2021 09:00:00 GMT 2:22 8c3c5783-9561-4a2e-931e-5374f3fb0522 false https://play.acast.com/s/hope-lies-in-dreams/hopeliesindreamstrailer 8c3c5783-9561-4a2e-931e-5374f3fb0522 f42701bf-0587-40dc-b698-a09087aea74f hopeliesindreamstrailer Trailer for upcoming 10-part series, Hope Lies in Dreams. trailer

Hosted on Acast. See acast.com/privacy for more information.

]]>

Hosted on Acast. See acast.com/privacy for more information.

]]>